Hybrid prehabilitation before lung surgery
Relative Effectiveness of a Hybrid Prehabilitation Program (Home-based and Center-based) Compared to a Center-based Prehabilitation Program Before Non-small Cell Lung Cancer Surgery: A Randomized Controlled Equivalence Study
This project will test whether a 15-session hybrid program combining home-based and center-based exercise improves aerobic fitness before lung resection in adults with non-small cell lung cancer.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 38 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | ADIR Association Academic / other |
| Locations | 1 site (Rouen) |
| Trial ID | NCT06866717 on ClinicalTrials.gov |
What this trial studies
This interventional comparison tests a 15-session hybrid prehabilitation program (home plus center sessions) against a standard 15-session center-based program for patients awaiting lung resection for non-small cell lung cancer. The primary outcome is change in aerobic capacity measured as peak oxygen uptake before and after the program. Eligible participants are adults referred for prehabilitation with peak VO2 below 20 ml/kg/min and with surgery scheduled at least four weeks away or not yet dated. The protocol excludes patients requiring oxygen during exercise, those with cardiac contraindications, or those undergoing neoadjuvant chemoradiotherapy.
Who should consider this trial
Good fit: Adults scheduled for lung resection for diagnosed or suspected non-small cell lung cancer who are referred for prehabilitation, live at home with another adult present, and have a peak oxygen uptake below 20 ml/kg/min.
Not a fit: Patients who require supplemental oxygen during exercise, have cardiological contraindications to exercise, are receiving neoadjuvant chemoradiotherapy, or have orthopedic/neurological/neuromuscular limitations to cycle ergometer training are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, this approach could make prehabilitation more accessible and improve patients' aerobic fitness before surgery, potentially reducing complications and shortening hospital stays.
How similar studies have performed: Previous center-based prehabilitation programs have shown reductions in postoperative complications and shorter hospital stays, while hybrid and telerehabilitation models are promising but less extensively validated.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \> 18 years * Patient scheduled to undergo lung resection for the treatment of diagnosed or suspected bronchial cancer * Referred for prehabilitation before lung resection surgery * Patient living at home with another adult present during exercise sessions * Surgery date not established at the time of inclusion in the program, or at least 4 weeks away * Peak oxygen uptake below 20 ml/kg/min * Affiliated with a health insurance system * Able to read and understand the information letter and sign the consent form Non-Inclusion Criteria: * Oxygen therapy during exercise * Cardiological contraindication to exercise training * Concomitant neoadjuvant chemoradiotherapy * Refusal to participate in a center-based prehabilitation training program * Orthopedic, neurological, vascular, or neuromuscular conditions limiting exercise training on a cycle ergometer * Patient under guardianship or curatorship * Pregnant or breastfeeding women Exclusion Criteria: -Withdrawal of consent
Where this trial is running
Rouen
- Association ADIR — Rouen, France (Recruiting)
Study contacts
- Principal investigator: Tristan Bonnevie, PhD — Association ADIR
- Study coordinator: Tristan Bonnevie, PhD
- Email: t.bonnevie@adir-hautenormandie.com
- Phone: 0235592970
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.