Hybrid PET-MR imaging for characterizing arrhythmogenic cardiomyopathies

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the effectiveness of a new hybrid PET-MR imaging tool in characterizing tissue and metabolic profiles of patients with arrhythmogenic cardiomyopathies (AC). By enrolling 80 patients with genetic AC, the study will assess the impact of myocardial inflammation on the phenotype and progression of the disease. The research will also explore associated immunological mechanisms and correlate findings with existing anatomical data. This approach seeks to provide a non-invasive method for understanding the disease better and improving patient outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male and female over 16 years old

Exclusion Criteria:

* Patients and their relatives with left ventricular or biventricular AC and carrier of a pathogenic or likely pathogenic variant in one of the following genes : PKP2, DSG2, DSC2, JUP, DSP, DES, FLNC, PLN, LMNA, TMEM43, CDH2, BAG3, RYR2, RBM20 Consent form

Exclusion Criteria :

* Sarcoidosis or known or diagnosed autoimmune disease
* History of myocardial infarction
* Patient under guardianship, curatorship or safeguard of justice

Where it's running

• CHU Angers
  Angers, France Recruiting
• CHU Brest
  Brest, France Recruiting
• CHU de Nantes
  Nantes, France Recruiting
• AP-HP La Salpêtrière
  Paris, France Recruiting
• CHU de Rennes
  Rennes, France Recruiting

Study contacts

• Principal investigator: Nicolas Piriou, PH — Nantes University Hospital
• Study coordinator: Nicolas Piriou, PH
• Email: nicolas.piriou@chu-nantes.fr
• Phone: 0253482781

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.