Hyaluronic acid wash to improve pregnancy outcomes in infertile women
the Effect of Hyaluronic Acid Platelets Rich Plasma on the Endometrial Receptivity and Intracytoplasmic Sperms Injection Outcome
This study tests if a special wash using hyaluronic acid can help improve the chances of pregnancy for women who are having trouble getting pregnant and are undergoing a specific fertility treatment.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Enrollment | 120 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | Female |
| Sponsor | Al-Nahrain University Academic / other |
| Locations | 1 site (AL-Kadimya, Baghdad Governorate) |
| Trial ID | NCT06937645 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effect of hyaluronic acid intrauterine wash on endometrial receptivity in infertile women undergoing intracytoplasmic sperm injection (ICSI). The procedure is performed on the day of oocyte retrieval, and the study measures various parameters related to endometrial receptivity, including subendometrial vasculature indices, before and after the intervention. The goal is to determine whether this treatment can enhance the chances of pregnancy outcomes for participants.
Who should consider this trial
Good fit: Ideal candidates are infertile females aged 18-40 who are scheduled for a fresh ICSI cycle using a GnRH antagonist protocol.
Not a fit: Patients with uterine pathology, poor responders, or endocrine diseases such as thyroid disorders or diabetes may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could improve pregnancy rates for infertile women undergoing ICSI.
How similar studies have performed: While the specific use of hyaluronic acid in this context is novel, similar studies exploring intrauterine treatments have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Infertile females aged 18-40 years. * Infertile females scheduled for GnRH antagonist protocol of fresh ICSI cycle. * Females use dual stimulation (GnRH agonist plus Ovetrelle) for ovulation triggering. Exclusion Criteria: * Infertile females diagnosed as a poor responder. * Infertile females diagnosed with uterine pathology. * Infertile females who are scheduled for a frozen ICSI cycle. * Infertile females diagnosed with endocrine diseases like thyroid disease, diabetes mellitus, and hyperprolactinemia. * Infertile females diagnosed with thrombocytopenia.
Where this trial is running
AL-Kadimya, Baghdad Governorate
- high institute for infertility diagnosis and ARTS — AL-Kadimya, Baghdad Governorate, Iraq (Recruiting)
Study contacts
- Study coordinator: ghada bassim raaf, Ph.D.
- Email: ghadaalanssari@yahoo.co.uk
- Phone: +9647714728261
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.