Human Sinonasal Mucosa Map Across Nasal Regions
Official title: Heterogeneity of Mucosa Across Different Human Sinonasal Sites: An Observational Study
Run by First Affiliated Hospital, Sun Yat-Sen University · NCT07692243 · Data updated 2026-11-12
This observational study will test whether tissues from different parts of the nose and sinuses have distinct biological features in adults undergoing sinus surgery.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | First Affiliated Hospital, Sun Yat-Sen University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Guangzhou, Guangdong) |
| Status | Recruiting |
| Started | December 1, 2025 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2028 |
| Registry record updated | July 9, 2026 |
| Trial ID | NCT07692243 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 years or older undergoing clinically indicated sinonasal surgery who can provide informed consent.
✕Probably not a fit
Participants without sinonasal disease or those not providing usable tissue may not gain direct benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Researchers will collect mucosal tissue from different sinonasal sites during clinically indicated surgery to compare tissue structure, gene and protein expression, and immune cell makeup. The study will describe site-specific differences in normal and inflamed mucosa and may help build a reference for future research on chronic rhinosinusitis and related conditions. No treatment or intervention will be given as part of the study, and relevant clinical information will be recorded to aid interpretation. Findings could lay groundwork for understanding how local biology varies across the sinonasal tract.
Why it matters
Potential benefit: If successful, the study could provide a reference map of site-specific sinonasal biology that may inform future diagnostics or targeted research.
How similar studies have gone: Other studies have demonstrated meaningful regional differences in mucosal biology in various tissues, supporting the value of this approach in the sinonasal tract.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 18 years or older. * Scheduled for clinically indicated sinonasal surgery. * Sinonasal mucosal tissue can be collected during surgery without significant additional risk. * Able and willing to provide written informed consent. * Relevant clinical information is available. Exclusion Criteria: * Unable or unwilling to provide informed consent. * Younger than 18 years of age. * Tissue collection may interfere with standard care or increase surgical risk. * History of sinonasal malignancy, sinonasal radiotherapy, or chemotherapy affecting sinonasal mucosa. * Active systemic infection or severe systemic disease affecting study participation or interpretation. * Use of systemic corticosteroids, immunosuppressants, or biologics within 4 weeks before surgery. * Insufficient or poor-quality tissue for planned analyses.
Where it's running
-
the First Affiliated Hospital of Sun Yat-sen University
Guangzhou, Guangdong, China Recruiting
Study contacts
- Study coordinator: YAN YAN, Master's Degree
- Email: yany38@mail2.sysu.edu.cn
- Phone: +8613016018473
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.