HOXB7 and related lung and blood biomarkers in pulmonary fibrosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot, multicenter observational study collects fresh lung tissue (from surgical biopsy, transbronchial cryobiopsy, or explant) and blood-derived exosomes from adults with suspected pulmonary fibrosis and from control patients undergoing lung resection for non-fibrotic conditions. Samples will undergo RNA sequencing and mass-spectrometry proteomic analysis to measure HOXB7 expression and linked molecular pathways. The project will compare molecular signatures across biopsy techniques and between fibrotic and non-fibrotic lungs. The aim is to identify tissue and circulating biomarkers associated with fibrosis progression and to inform less invasive monitoring strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18 to 80 with clinical suspicion of pulmonary fibrosis
* Availability of fresh lung tissue from biopsy or lung explant
* Signed informed consent for research use of biological material and data

Exclusion Criteria:

\- Refusal to sign informed consent

Where it's running

• Azienda Ospedaliero Universitaria Policlinico di Modena
  Modena, Italy Recruiting

Study contacts

• Study coordinator: Roberto Tonelli
• Email: rtonelli@unimore.it
• Phone: +390594225934

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.