How time on dialysis and urine output affect bladder size and flexibility in people waiting for a kidney transplant
Official title: IMPACT OF DIALYSIS DURATION AND DIURESIS ON BLADDER CAPACITY AND COMPLIANCE IN END STAGE RENAL DISEASE PATIENTS AWAITING RENAL TRANSPLANT
Run by Sindh Institute of Urology and Transplantation · NCT07570771 · Data updated 2026-11-12
See if longer time on dialysis and lower urine output make the bladder smaller and less flexible in adults with end-stage kidney disease who are awaiting a transplant.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 87 (estimated) |
| Sponsor | Sindh Institute of Urology and Transplantation Academic / other |
| Locations | 1 site (Karachi, Sindh) |
| Status | Recruiting |
| Started | February 2, 2026 |
| Main results expected | February 2027 |
| Study ends | February 2027 |
| Registry record updated | May 6, 2026 |
| Trial ID | NCT07570771 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–65 with end-stage renal disease on maintenance dialysis for 6–24 months, awaiting renal transplantation, with ESRD from non-urological causes and without conditions or medications affecting bladder function.
✕Probably not a fit
Patients with diabetes, neurogenic bladder, prior urological surgery, active urinary tract infection, pre-existing lower urinary tract symptoms before dialysis, or other neurological/systemic diseases affecting bladder function are excluded and unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective observational study at the Sindh Institute of Urology and Transplantation (SIUT) in Karachi that follows adults with end-stage renal disease on maintenance dialysis who are awaiting kidney transplant. Adults aged 18–65 who have been on dialysis for 6–24 months will have demographic and clinical data recorded and urine output measured with frequency-volume charts. Participants will undergo laboratory testing, imaging, and urodynamic studies to measure bladder capacity and compliance. The study will correlate dialysis duration and residual urine output with urodynamic findings to inform pre-transplant evaluation and potential post-transplant urological management.
Why it matters
Potential benefit: If successful, the results could help identify patients at risk for reduced bladder capacity or poor compliance and guide pre- and post-transplant urological care to improve transplant outcomes.
How similar studies have gone: Previous reports have observed bladder shrinkage and compliance changes in long-term dialysis patients, but the data are limited and variable, so this specific prospective characterization remains relatively under-described.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18-65 years diagnosed with end-stage renal disease (ESRD) * Patients on maintenance dialysis for a duration of 6 to 24 months * ESRD secondary to non-urological causes * Patients awaiting renal transplantation Exclusion Criteria: * Patients with diabetes mellitus * Patients with neurogenic bladder * Patients with prior urological surgeries * Patients with active urinary tract infection * Patients with pre-existing lower urinary tract symptoms before dialysis * Patients on medications affecting lower urinary tract function * Patients with neurological or systemic diseases affecting bladder function
Where it's running
-
Sindh Institute of Urology and Transplantation (SIUT)
Karachi, Sindh, Pakistan Recruiting
Study contacts
- Study coordinator: Dr. Anum Fatima Parekh, FCPS
- Email: anum.parekh@yahoo.com
- Phone: +92-333-3305227
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.