How sleep affects your microbiome
The Effects of Sleep on Human Microbiota: Implications for Health and Disease
This study will test whether short-term sleep loss changes the body's microbiome in adults, especially in people with abnormal sleep patterns.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 5000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Trial ID | NCT02573753 on ClinicalTrials.gov |
What this trial studies
This is a pilot interventional study examining how changes in sleep affect human microbial communities. Participants undergo controlled sleep restriction (and related weight change protocols) with microbial samples collected before and after the intervention to compare community composition. The study enrolls adults who are eligible for concurrent IRB-approved protocols and excludes pregnant or breastfeeding participants. Findings will be used to explore links between sleep, microbiota shifts, and potential disease risk.
Who should consider this trial
Good fit: Adults enrolled in qualifying IRB-approved studies at Mayo Clinic who are not pregnant or breastfeeding and can complete short-term sleep and weight-related protocols are ideal candidates.
Not a fit: People who are pregnant or breastfeeding, who cannot alter their sleep or weight as required, or who are not enrolled in a qualifying IRB-approved protocol are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, this could help doctors use microbiome changes to spot health risks linked to poor sleep earlier.
How similar studies have performed: Early research suggests sleep can influence the microbiome but intervention data are limited, so this pilot explores a relatively novel application.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Only subjects who are eligible for ongoing IRB-approved studies will be deemed eligible for this protocol. Exclusion Criteria: * Pregnant or breast-feeding women * Subjects who are ineligible for ongoing IRB-approved studies will not be included in this protocol
Where this trial is running
Rochester, Minnesota
- Mayo Clinic Rochester — Rochester, Minnesota, United States (Recruiting)
Study contacts
- Principal investigator: Virend Somers, MD, PhD — Mayo Clinic
- Study coordinator: Nick Wozniak
- Email: Wozniak.Nicholas@mayo.edu
- Phone: 507-255-8794
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.