How skin tone affects pulse oximeter oxygen readings

The Impact of Skin Tone on Pulse Oximeter Accuracy

Rush University Medical Center · NCT07415187

This study will see if pulse oximeters give different oxygen readings in adults with different skin tones by comparing their readings to arterial blood gas measurements.

Quick facts

Study typeObservational
Enrollment194 (estimated)
Ages18 Years and up
SexAll
SponsorRush University Medical Center (other)
Locations1 site (Chicago, Illinois)
Trial IDNCT07415187 on ClinicalTrials.gov

What this trial studies

This observational cohort enrolls adult patients at Rush who are already having an arterial blood gas (ABG) taken as part of routine care. At the moment the ABG sample is obtained, two commercially available pulse oximeters are temporarily placed on a finger to record oxygen saturation values. The oximeter readings will be directly compared with the arterial oxygen saturation from the ABG to measure differences across a range of skin pigmentation. Patients with factors that interfere with finger sensors (heavy scarring, tremor, or nonremovable opaque nail polish) are excluded.

Who should consider this trial

Good fit: Adults at Rush University Medical Center who already have an arterial blood gas ordered (in the ICU, general wards, or pulmonary clinics) and who can have pulse oximeter sensors placed on a finger are ideal candidates.

Not a fit: People who are not having an arterial blood gas, children, or those with heavy finger scarring, significant hand tremor, or nonremovable opaque nail polish are unlikely to be eligible or to benefit from participation.

Why it matters

Potential benefit: If successful, the results could improve pulse oximeter use and help ensure low oxygen levels are detected reliably across different skin tones.

How similar studies have performed: Previous research has reported racial and skin-pigmentation differences in pulse oximeter accuracy, so this study builds on existing findings rather than being wholly novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients admitted to an intensive care unit, general medicine/surgery wards, or visiting the pulmonary function labs and/or outpatient pulmonary services clinics at Rush University Medical Center
* Patient has an existing order for an arterial blood gas analysis \[arterial line or puncture\]

Exclusion Criteria:

* Patients with heavy scar tissue on the sensor site
* Patients with hand tremors
* Opaque nail polish that cannot be removed

Where this trial is running

Chicago, Illinois

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Accuracy of Pulse Oximetry Across Skin Pigmentation Levels

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.