How severe obstructive sleep apnea affects the brain's processing of sounds and attention

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will compare 50 adults with PSG-confirmed severe OSAHS to 50 age- and sex-matched healthy controls. Participants will undergo a one-night polysomnography, cognitive screening (MoCA), standard hearing checks, and a 1.5–2 hour EEG session using passive and active oddball sound tasks. The passive task measures automatic sound-change detection while the active task measures attention to rare sounds, with EEG event-related potentials analyzed for auditory-cognitive markers. Researchers aim to identify EEG signatures that differ between groups and could signal early hearing-related cognitive problems in OSAHS.

Why it matters

Who can join: the full rules

Inclusion Criteria:

All Participants:

* Aged 20-60 years
* Normal hearing (PTA ≤25 dB HL at 0.5,1,2,4 kHz; Type A tympanogram)
* MoCA score ≥26
* Willing to complete EEG testing

OSAHS Group Additional:

\- PSG-confirmed severe OSAHS (AHI \>30 events/hour)

Control Group Additional:

* Self-reported absence of snoring/sleep disorders
* No prior OSAHS diagnosis

Exclusion Criteria:

All Participants:

* History of:

  * Schizophrenia, epilepsy, Parkinson's, TBI, or language disorders
  * Middle/inner ear diseases (otitis media, acoustic neuroma, etc.)
  * Cognitive impairment or depression/anxiety disorders
* Chronic steroid use
* Systemic inflammatory diseases or malignancies
* Pregnancy or suspected pregnancy (self-reported)

Where it's running

• Peking University First Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Caifeng Xia, M.D.
• Email: xiacf@pku.edu.cn
• Phone: +8618811173785

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.