How seasonal changes affect biological age in adults.
Evaluation of the Effect of Seasonality on Biological Age in Adults
We will test whether seasonal changes influence biological age measurements in adults aged 40 and older.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 40 Years and up |
| Sex | All |
| Sponsor | Société des Produits Nestlé (SPN) Industry-sponsored |
| Locations | 1 site (Lausanne, CH) |
| Trial ID | NCT07242833 on ClinicalTrials.gov |
What this trial studies
This observational study will enroll adults aged 40 and above who are generally healthy or have stable chronic conditions and collect biological samples (blood or saliva) at multiple times across the year. Researchers will measure molecular markers such as DNA methylation patterns and plasma proteomics to calculate biological age and age acceleration. The design uses repeated measurements across seasons at a clinical lab in Lausanne, Switzerland to detect seasonal shifts in biological-clock signals. Findings are intended to inform timing and interpretation of long-term lifestyle interventions targeting biological aging.
Who should consider this trial
Good fit: Adults 40 years and older who are in generally good health or have stable, well-controlled chronic conditions, with BMI ≥18.5 kg/m², who can consent and attend visits at the Lausanne clinical lab.
Not a fit: People under 40, those with unstable or serious medical or psychiatric conditions, or those unable to travel to the Lausanne site or follow study procedures are unlikely to benefit.
Why it matters
Potential benefit: If successful, this could help researchers and clinicians time measurements more accurately and improve the design of interventions aimed at slowing biological aging.
How similar studies have performed: Some prior research has shown seasonal effects on certain blood biomarkers, but applying seasonality specifically to DNA methylation–based biological clocks is relatively novel and has limited prior evidence.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Males and females aged over 40 years, inclusive, at enrolment. 2. Assessed by the investigator to be in general good health or have stable, well-controlled chronic medical conditions (e.g. hypertension, type 2 diabetes, etc.) that are not expected to interfere with study participation or outcomes. (Note: stable medical condition is defined as controlled medical condition, with no change in medication, worsening of the condition, or hospitalization in the past 3 months prior to enrolment). 3. Body mass index (BMI) ≥18.5 kg/m². 4. Able to understand and to sign a written informed consent prior to study enrolment. 5. Willing and able to comply with the requirements for participation in this study. Exclusion Criteria: 1. Any past or on-going significant medical/surgical condition and/or psychiatric condition, which in the opinion of the investigator may risk participant's wellbeing/safety, impede participant compliance with study procedures or ability to complete the study and/or could confound the primary objectives of the study (such as seasonal allergy). 2. Any acute illness or any recent medical/surgical intervention, including vaccination, within 21 days prior to enrolment. 3. Female participants who are pregnant or intending to become pregnant, lactating and/or breastfeeding 4. Currently participating in another interventional research study. 5. Family or direct hierarchical relationship with the research team members.
Where this trial is running
Lausanne, CH
- Clinical Lab — Lausanne, Ch, Switzerland (Recruiting)
Study contacts
- Principal investigator: Carolina Stambolsky, MD — Nestlé Research
- Study coordinator: Ambra Giorgetti, PhD
- Email: ambra.giorgetti@rd.nestle.com
- Phone: +41765218487
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.