How radiation affects cervical cancer biology and treatment side effects
Understanding the Biological Drivers of Cervical Cancer and Side Effects From Radiation Therapy
We will see if radiation therapy changes tissue factor and other molecular markers in women receiving radiation for cervical cancer by collecting blood and tumor samples before, during, and at the end of treatment.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | University of California, San Diego Academic / other |
| Drugs / interventions | radiation, chemotherapy, immunotherapy |
| Locations | 1 site (La Jolla, California) |
| Trial ID | NCT07121543 on ClinicalTrials.gov |
What this trial studies
This observational study collects blood and tumor or vaginal biopsies from women with cervical cancer who are scheduled to receive brachytherapy as part of their standard chemo‑radiation care. Samples are taken before treatment, during therapy, and on the last day of radiation to measure tissue factor and other molecular changes over time. The investigators will use these specimens for translational laboratory analyses to identify pathways altered by radiation. Findings could point to molecular targets for future targeted radiotherapy or immunotherapy approaches.
Who should consider this trial
Good fit: Adults (18+) with a pathological diagnosis of cervical cancer who are scheduled to receive brachytherapy and can provide blood and tissue samples are ideal candidates.
Not a fit: Patients seeking direct therapeutic benefit should note this is an observational sample‑collection study and those who are pregnant, lactating, or unable to provide tissue are not eligible and would not benefit from participation.
Why it matters
Potential benefit: If successful, the study could reveal biological changes caused by radiation that lead to new targeted treatments or strategies to reduce side effects for women with cervical cancer.
How similar studies have performed: Prior translational studies have shown that radiotherapy can change tumor immune and molecular markers, though focusing on tissue factor in this context is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years or older * Pathological diagnosis of cervical cancer * Scheduled to receive brachytherapy for cervical cancer Exclusion Criteria: * Pregnancy or lactation * Inability to provide a tissue sample
Where this trial is running
La Jolla, California
- University of California San Diego — La Jolla, California, United States (Recruiting)
Study contacts
- Principal investigator: Jyoti Mayadev, MD — University of California, San Diego
- Study coordinator: Jyoti Mayadev, MD
- Email: CancerCTO@health.ucsd.edu
- Phone: 858-822-5354
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.