How premorbid personality relates to recovery after stroke or severe brain injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective observational study that follows patients admitted for rehabilitation after stroke or severe acquired brain injury to track recovery over time. Participants receive standardized cognitive, motor, psychological, behavioral, personality, and disability assessments at admission (T0), at discharge (T1), and again at 12 months for stroke or 18 months for sABI (T2). Inclusion requires specific post-event time windows (3–30 days for stroke, 7–90 days for sABI), a Level of Cognitive Functioning score ≥6 for sABI patients, and a caregiver able to help complete premorbid personality questionnaires. The study compares short- and long-term global cognitive recovery, autonomy, motor skills, psycho-behavioral functioning, and social participation by premorbid personality profiles.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* diagnosis of one of the following two conditions:
* Severe Acquired Brain Injury (sABI) of traumatic or non-traumatic etiology; the term sABI includes acute brain injuries of traumatic or non-traumatic origin (vascular, infectious, metabolic, or anoxic), in which the patient initially presents with a coma state (Glasgow Coma Scale - GCS less than 8) and simultaneously exhibits motor, sensory, cognitive, and/or behavioral impairments.
* Ischemic or hemorrhagic stroke without features of Severe Acquired Brain Injury (sABI) (Glasgow Coma Scale \[GCS\] score ≥ 8 and no alteration of consciousness).
* Time from injury between:
* 7 and 90 days for Severe Acquired Brain Injury (sABI) patients
* 3 and 30 days for stroke patients
* Level of Cognitive Functioning (LCF) score ≥ 6 for sABI patients
* Signed informed consent for study participation
* Presence of a support family member (caregiver) able to assist with completing the personality questionnaire (HEXACO Adjective Scale, HAS)

Exclusion Criteria:

* Pre-existing neurological pathology
* Severe aphasia or severe inattention that precludes administration of the tests required by the protocol, as identified during cognitive screening.
* Patients with a language barrier due to insufficient proficiency in Italian.
* Particularly vulnerable populations:

The following patients will be excluded from the study: patients in emergency situations.

Where it's running

• Sezione medicina fisica e riabilitativa dipartimento di neuroscienze, verona
  Verona, Vr, Italy Recruiting

Study contacts

• Study coordinator: Valentina Varalta
• Email: valentina.varalta@univr.it
• Phone: 0458124956

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.