How prebiotic and common sodas affect fullness and blood sugar in young men
Effect of Carbonated Prebiotic Beverages Versus Caloric and Non-caloric Beverages on Satiety, Glucose, Insulin, and GLP-1 Response in Healthy Male Participants
This test will see if prebiotic sodas (Olipop, Poppi) make healthy men aged 18-40 feel fuller and change their blood sugar, insulin, and GLP-1 responses compared with Diet Coke and Coca-Cola Classic.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 10 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | Male |
| Sponsor | Texas Christian University Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Fort Worth, Texas) |
| Trial ID | NCT07105826 on ClinicalTrials.gov |
What this trial studies
This single-blind, randomized crossover trial enrolls healthy men aged 18-40 with BMI 18.5-24.9 who will each consume Olipop, Poppi, Diet Coke, and Coca-Cola Classic in separate visits. Participants fast 8-12 hours before four lab visits at TCU spaced over four weeks, and each visit includes beverage consumption followed by repeated measurements of hunger ratings, plasma glucose, insulin, and GLP-1. Secondary endpoints include body composition, beverage palatability, and gastrointestinal symptoms, and investigators will collect finger-stick glucose and HbA1c as baseline measures. The crossover design lets each participant serve as his own control to compare acute metabolic and satiety responses across beverages.
Who should consider this trial
Good fit: Ideal candidates are healthy, non-smoking men aged 18-40 with a BMI of 18.5-24.9 kg/m² who are not taking medications or supplements that affect glucose and have no major medical conditions.
Not a fit: People outside the age or BMI ranges, women, individuals with diabetes, gastrointestinal, liver, kidney, or cardiovascular disease, current tobacco users, those with phenylketonuria, or anyone taking glucose-affecting medications are unlikely to qualify or benefit from the results.
Why it matters
Potential benefit: If successful, results could identify whether prebiotic sodas increase satiety and GLP-1 without raising blood sugar, suggesting a lower-glycemic beverage option.
How similar studies have performed: Previous studies show some prebiotic fibers can boost GLP-1 and feelings of fullness while sugary drinks raise glucose and insulin, but acute comparisons of commercial prebiotic sodas versus diet and regular cola products are limited and results are mixed.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Gender: Male * Age: 18-40 years * Health Status: Healthy, with no significant medical conditions * Body Mass Index (BMI): 18.5-24.9 kg/m² Exclusion Criteria * Diabetes: Diagnosed diabetes (Type 1 or Type 2) * Gastrointestinal Disorders: Any diagnosed gastrointestinal conditions (e.g., irritable bowel syndrome, inflammatory bowel disease) * Liver Disease: Any diagnosed liver conditions * Kidney Disease: Any diagnosed kidney conditions * Cardiovascular Disease: Any diagnosed cardiovascular conditions * Hypertension: Diagnosed high blood pressure * Recent Illness or Infection: Any illness or infection within the past 30 days that could affect study outcomes * Tobacco or Nicotine Use: Current use of tobacco or nicotine products (e.g., smoking, vaping) * Phenylketonuria (PKU): A genetic disorder affecting phenylalanine metabolism, due to the presence of aspartame in Diet Coke * Medication Use: Use of medications or supplements that affect glucose metabolism, insulin response, or appetite * Intermittent Fasting: Engagement in intermittent fasting or inconsistent time-restricted feeding patterns * Other Health Conditions: Any other health conditions that, in the opinion of the investigators, could interfere with study participation or outcomes
Where this trial is running
Fort Worth, Texas
- Texas Christian University — Fort Worth, Texas, United States (Recruiting)
Study contacts
- Study coordinator: Elisa Marroquin, Ph.D.
- Email: E.Marroquin@tcu.edu
- Phone: 469-491-6443
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.