How PICS affects breathing during weaning from prolonged mechanical ventilation
Official title: Impact of Persistent Inflammation-Immunosuppression-Catabolism Syndrome (PICS) on the Respiratory Physiology in Patients With Prolonged Mechanical Ventilation
Run by National Taiwan University Hospital · NCT07002710 · Data updated 2026-11-12
This project will test whether people with PICS have more lung collapse, lower oxygen levels, and higher breathing effort when trying to wean from long-term ventilator support.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 20 Years and up |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | National Taiwan University Hospital Academic / other |
| Locations | 1 site (Taipei) |
| Status | Recruiting |
| Started | March 18, 2025 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | June 3, 2025 |
| Trial ID | NCT07002710 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults who have used a respirator continuously for at least 10 days, are transferred to the Respiratory Care Center with stable vital signs and FiO2 ≤ 60%, and are willing and able to attempt weaning are ideal candidates.
✕Probably not a fit
Patients who are pregnant, who refuse weaning, who lack spontaneous breathing ability, or who are hemodynamically or respiratory unstable (e.g., needing >60% oxygen) are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Investigators will enroll 60 patients who have been on mechanical ventilation for at least 10 days and are transferred to a respiratory care center for weaning. Patients will be classified as PICS or non-PICS using laboratory analyses and biomarkers. During weaning trials the team will collect respiratory-physiology measures (oxygenation changes, work of breathing, diaphragm ultrasound, esophageal pressure, electrical impedance tomography), infection data, and inflammatory biomarkers. The one-year project aims to compare the prevalence of PICS in stable prolonged-ventilation patients and to identify differences in respiratory physiology and weaning outcomes between groups.
Why it matters
Potential benefit: If successful, the findings could help personalize weaning strategies and reduce lung injury, weaning failure, and complications among prolonged mechanically ventilated patients with PICS.
How similar studies have gone: Prior studies have described PICS prognosis in ICU populations, but applying detailed respiratory-physiology measurements during weaning in respiratory care centers is largely novel and not yet proven.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients are still receiving ventilator support when transferred to the ward where the study is conducted. * Use the respirator continuously for at least 10 days. * Vital signs are stable: blood pressure systolic blood pressure is not lower than 70 mmHg; heartbeat is not lower than 50/min and not higher than 160/min; respiratory rate is not higher than 50/min. * When using respirator support, the oxygen concentration should not exceed 60%. Exclusion Criteria: ．At least one of the following conditions occurs: 1. Pregnancy. 2. The patient refuses to undergo weaning from the respirator training. 3. The patient has no ability to drive spontaneous breathing.
Where it's running
-
National Taiwan University Hospital
Taipei, Taiwan Recruiting
Study contacts
- Study coordinator: Jih-Shuin Jerng, MD, PhD, Principal Investigator
- Email: jsjerng@ntu.edu.tw
- Phone: +886-2-23123456
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Long-Term Recovery and Quality of Life after Sepsis in ICUs
This international study follows adults with sepsis in ICUs to see how their quality of life and other outcomes look six months later.
-
Personalized music for distress after ICU discharge
In people who have left intensive care, this study tests whether listening to self-chosen music can lessen daily distress and improve mood and quality of life.
-
Behavioral health collaborative care for people recovering after ICU
This trial will test whether a coordinated behavioral health program using a digital app, coaching, and psychiatric support helps ICU survivors reduce anxiety, depression, and PTSD symptoms.
-
Tracking long-term health and family effects after intensive care in the DACH region
This project will try to follow adults who spent more than 72 hours in the ICU and their families to see which factors lead to lasting physical, cognitive, or mental health problems.
-
Evaluating the impact of diaries for ICU patients and their families
This study is testing if giving diaries to ICU patients and their families helps improve their mental health and quality of life compared to standard care.
-
Mobile health program for rehabilitation after COVID-19
This study is testing a mobile health program that uses high intensity exercise to help 120 patients recover better after being seriously ill with COVID-19.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.