How pet cats change the nose and gut microbiome in people with cat allergies
Official title: Effects of Pet Cats on Nasal and Intestinal Microorganisms in Patients With Allergic Rhinitis Who Are Allergic to Cat Allergen
Run by The First Affiliated Hospital with Nanjing Medical University · NCT07110311 · Data updated 2026-11-12
This project tests whether living with a pet cat changes the nasal and gut microbiomes in adults with allergic rhinitis who are sensitized to cat allergens.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | The First Affiliated Hospital with Nanjing Medical University Academic / other |
| Locations | 1 site (Nanjing, Jiangsu) |
| Status | Recruiting |
| Started | November 14, 2024 |
| Main results expected | November 1, 2026 |
| Study ends | November 1, 2032 |
| Registry record updated | August 7, 2025 |
| Trial ID | NCT07110311 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18–65 with moderate to severe allergic rhinitis who test positive for cat allergen sensitization and are willing to provide nasal and stool samples.
✕Probably not a fit
People with other nasal diseases (for example nasal tumors or papilloma), children, those not sensitized to cat allergens, or those unwilling to provide specimens are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational study enrolling adults (18–65) with moderate to severe allergic rhinitis and confirmed cat allergen sensitization seen at the First Affiliated Hospital of Nanjing Medical University. Participants provide nasal and stool specimens and complete questionnaires about pet exposure and symptoms, with no investigational treatment given. The study compares microbiome patterns between patients who live with pet cats and those who do not to look for differences that might relate to allergy severity. Findings aim to link real-world pet exposure to specific nasal and gut microbial signatures.
Why it matters
Potential benefit: If successful, the results could help clinicians give clearer advice about pet ownership and point toward microbiome-informed approaches to reduce allergy symptoms.
How similar studies have gone: Prior studies have shown that pet exposure can change gut and airway microbiomes and influence allergy risk, but focused work specifically on nasal and gut microbiota in cat-allergic adults is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients (18-65 years). * Patients with moderate to severe dust mite allergic rhinitis were diagnosed based on clinical history and positive cat allergen sensitization tests (skin prick test and/or specific IgE). * Patients who visited the Department of Otolaryngology of the First Affiliated Hospital of Nanjing Medical University. Exclusion Criteria: * Patients who refused to accept specimen and questionnaire collection. * Patients who had nasal diseases other than allergic rhinitis, such as nasal papilloma and nasal malignant tumor.
Where it's running
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The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000
Nanjing, Jiangsu, China Recruiting
Study contacts
- Study coordinator: Lei Cheng, PhD
- Email: chenglei@jsph.org.cn
- Phone: +8613776620807
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.