How OR6A2 and octanal on monocytes relate to outcomes after myocardial ischemia-reperfusion injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational study of patients who experienced myocardial ischemia-reperfusion injury after primary percutaneous coronary intervention. Investigators measure OR6A2 expression on monocyte subtypes, plasma octanal, and systemic oxidative stress and inflammatory biomarkers from blood samples taken after revascularization. They then correlate these molecular profiles with major adverse cardiovascular events identified during a 44-month clinical follow-up. The goal is to identify biomarker patterns that predict clinical outcomes and could support personalized risk stratification after revascularization.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Acute myocardial infarction (AMI) patients with angiographically-confirmed coronary artery disease undergoing primary percutaneous coronary intervention (PCI), and subsequently diagnosed with protocol-defined myocardial ischemia-reperfusion injury during the post-PCI period.
2. Age 18-90 years inclusive.

Exclusion Criteria:

1. Active systemic infections.
2. Advanced heart failure (NYHA class III-IV).
3. Acute cerebrovascular conditions.
4. Active myocarditis.
5. cardiomyopathy.
6. Refractory ventricular tachycardia/fibrillation.
7. Diagnosis/concurrent treatment for malignancy within 5 years (except non-melanoma skin cancer/carcinoma in situ).
8. Severe renal insufficiency (estimated glomerular filtration rate \[eGFR\] \<30 mL/min/1.73m2 or dialysis dependence).
9. Child-Pugh class C hepatic dysfunction.

Where it's running

• Department of Cardiology, Zhongda Hospital, Southeast University
  Nanjing, Jiangsu, China Recruiting

Study contacts

• Study coordinator: Wenbin Lu, PhD
• Email: 101012092@seu.edu.cn
• Phone: +86 13605185175

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.