How one day of very low activity changes next-day exercise response
Official title: A Single Day of Inactivity on the Systemic Metabolic and Inflammatory Exercise Response
Run by Concordia University Wisconsin · NCT07429370 · Data updated 2026-11-12
This project will test whether one day of very low activity changes how healthy 18–30-year-olds' bodies respond to exercise the next day.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 30 Years |
| Sex | All |
| Enrollment | 6 (estimated) |
| Sponsor | Concordia University Wisconsin Academic / other |
| Locations | 1 site (Mequon, Wisconsin) |
| Status | Recruiting |
| Started | January 1, 2026 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | February 24, 2026 |
| Trial ID | NCT07429370 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal participants are healthy 18–30-year-olds without acute or chronic cardiopulmonary, liver, kidney, or metabolic disease, not taking metabolism-altering medications, non-smokers, and without orthopedic limitations.
✕Probably not a fit
People older than 30, those with chronic diseases, current smokers, or anyone taking metabolism-related medications (e.g., statins, metformin, GLP-1 agonists) are unlikely to match the study population and may not benefit from these findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Healthy young adults will reduce their daily steps (to under 5,000) for one day and then complete a standardized bout of aerobic exercise while researchers collect blood and other samples. The study will measure circulating metabolomics and proteomics and compare RNA profiles at rest and during exercise after normal and low-activity days. Analyses will focus on carbohydrate utilization, inflammation-related pathways, metabolism, and innate immunity to explain altered exercise responses. The goal is to link a short period of inactivity to specific molecular changes that modify the physiological effects of exercise.
Why it matters
Potential benefit: If successful, this work could identify biological signals to help tailor activity recommendations so people get more benefit from each exercise session.
How similar studies have gone: Earlier smaller studies have shown increased carbohydrate use and RNA changes after a day of reduced activity, but comprehensive metabolomics and proteomics profiling in this exact context is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * • between the ages of 18-30 years old Exclusion Criteria: * • free from acute or chronic illness (cardiac, pulmonary, liver, or kidney abnormalities, cancer, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other known metabolic disorders) * do not take medications related to metabolism (i.e., statins, metformin, GLP-1 agonists) * free from orthopedic limitations (including any artificial joints) * currently smoke or participate in other forms of tobacco use.
Where it's running
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Concordia University of Wisconsin
Mequon, Wisconsin, United States Recruiting
Study contacts
- Study coordinator: Kevin J Gries, PhD
- Email: kevin.gries@cuw.edu
- Phone: 2622434293
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.