How often thinking and memory get worse after surgery in people who already have memory problems

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center, prospective, single-arm cohort follows adults aged 60 and older with preexisting mild cognitive impairment who undergo elective non-cardiac surgery under general anesthesia to measure postoperative cognitive decline (POCD). Preoperative screening uses the Mini-Cog followed by MMSE and MoCA-B for those who screen positive, and postoperative neuropsychological testing tracks changes over time. A separate normative sample of cognitively normal older adults is recruited to define expected test score variation without surgery rather than to serve as an intervention control group. The study is conducted at Peking University Shenzhen Hospital and focuses on incidence estimates to inform perioperative care for this population.

Why it matters

Who can join: the full rules

1. Preexisting Cognitive Impairment (PreCI) Surgical Group

   Inclusion Criteria:
   * Age ≥ 60 years
   * Preoperative screening with MMSE and MoCA-B indicating mild cognitive impairment (MCI) or mild dementia
   * Undergoing elective non-cardiac surgery under general anesthesia

   Exclusion Criteria:
   * Expected difficulty in completing neuropsychological assessments (e.g., inability to communicate in Mandarin, blindness, or deafness)
   * Usual residence outside Shenzhen
2. Normative Reference Group

Inclusion Criteria:

* Age ≥ 60 years
* No history of general anesthesia surgery within the past 12 months
* Mini-Cog score \> 1

Exclusion Criteria:

* Planned elective surgery under general anesthesia within the next 12 months
* History of suspected or diagnosed cognitive impairment, or screening indicating cognitive impairment using MMSE and MoCA-B
* Expected difficulty in completing neuropsychological assessments (e.g., inability to communicate in Mandarin, blindness, or deafness)
* Usual residence outside Shenzhen

Where it's running

• Peking University Shenzhen Hospital
  Shenzhen, Guangdong, China Recruiting

Study contacts

• Study coordinator: Yaqian Yu
• Email: meayaqian@gmail.com
• Phone: +86 13528403653

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.