How often older adults with cancer get a big drop in blood pressure right after anesthesia induction
A Prospective Observational Study to Determine the Incidence and Risk Factors of Post-Induction Hypotension in Geriatric Oncologic Patients Undergoing General Anesthesia at a Tertiary Oncology Center
We will test how often and why older adults with cancer have a large drop in blood pressure within the first 20 minutes after being put under general anesthesia.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 140 (estimated) |
| Ages | 65 Years and up |
| Sex | All |
| Sponsor | Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Ankara, Ankara) |
| Trial ID | NCT07294040 on ClinicalTrials.gov |
What this trial studies
This is a prospective observational study at a single oncology hospital that will record hemodynamic data before and during the first 20 minutes after anesthesia induction in patients aged 65 and older with cancer. Standard monitoring plus perfusion index (PI) and pleth variability index (PVI) readings will be taken and averaged from the non-cannulated hand, and induction drugs and doses will be documented. Demographics, comorbidities, cancer type and treatments, preoperative labs, medications, and ASA score will be collected to analyze associations with post-induction hypotension (PIH), defined as a ≥30% drop in mean arterial pressure or MAP below 65 mmHg within 20 minutes before surgical stimulation. The goal is to identify frequency and modifiable risk factors to inform perioperative management for geriatric oncology patients.
Who should consider this trial
Good fit: Adults aged 65 years or older with a confirmed cancer diagnosis scheduled for surgery under general anesthesia who are ASA class II–IV and can provide written informed consent.
Not a fit: Patients younger than 65, those having regional anesthesia, those already on vasopressors before surgery, or those with uncontrolled hypertension, advanced heart failure, or severe arrhythmias are excluded and unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, the findings could help anesthesiologists reduce episodes of dangerous low blood pressure in older cancer patients by guiding tailored perioperative monitoring and management.
How similar studies have performed: Previous observational work has identified risk factors for post-induction hypotension in elderly surgical populations, but data specifically focused on geriatric oncology patients and the predictive value of PI/PVI are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults ≥65 years of age Patients with a diagnosis of cancer and scheduled for surgery Ability and willingness to provide written informed consent ASA physical status class II-IV Exclusion Criteria: Patients under 65 years of age Patients without a confirmed oncologic diagnosis Refusal to provide written informed consent Patients undergoing regional anesthesia Patients with tracheostomy or requiring multiple intubation attempts History of peripheral arterial disease Use of vasopressors before the start of surgery Uncontrolled hypertension (blood pressure \>180/110 mmHg) Advanced heart failure (Ejection Fraction \<40%) Severe arrhythmias such as atrial fibrillation or significant ventricular arrhythmias that preclude reliable hemodynamic monitoring
Where this trial is running
Ankara, Ankara
- Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital — Ankara, Ankara, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Dolunay arık
- Email: arikdolunay@gmail.com
- Phone: +90 0554 977 44 97
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.