How often midline IV catheters are replaced and why

Study of the Prevalence of Midline Replacements and the Reasons for These Replacements

See how often midline IV catheters are replaced and the reasons for those replacements in adults who receive a midline.

Quick facts

• Study type: Observational
• Enrollment: 984 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Centre Hospitalier de Valenciennes (network)
• Locations: 1 site (Valenciennes)
• Trial ID: NCT07394296 on ClinicalTrials.gov

What this trial studies

This observational study at Centre Hospitalier de Valenciennes will record the frequency of midline catheter replacements and the reasons for replacement in adult patients. Adults over 18 who consent and receive a first midline of at least 14 cm for an expected treatment duration of up to 28 days are eligible, while patients without social security coverage, with failed insertion, or under guardianship are excluded. Study staff will collect information on catheter dwell time, reasons for removal or replacement (for example infection, occlusion, thrombosis, or mechanical issues), and any complications noted during routine care. No experimental treatments are given; clinicians will insert and manage midlines according to local practice and the study will analyze real-world patterns and outcomes.

Who should consider this trial

Good fit: Ideal candidates are adults (18+) who consent and receive a first midline catheter of at least 14 cm at the participating hospital for an expected treatment of 28 days or less.

Not a fit: Patients who need long-term central venous access (like PICC or CVC), children, those with failed midline insertion, under guardianship, or without social security coverage are unlikely to benefit from participation.

Why it matters

Potential benefit: If successful, the findings could help clinicians choose and manage midlines better to reduce unnecessary replacements and preserve patients' venous access.

How similar studies have performed: Previous studies have reported mixed complication rates and variable durations of midline use, so this observational work aims to clarify real-world replacement patterns rather than test a new device.

Eligibility criteria

Inclusion Criteria:

* Patients over 18 years of age.
* Patients who have given their consent to participate in the study.
* Patients treated in a hospital unit authorized to insert midlines, or who have a midline inserted by a professional trained in this procedure, in accordance with the local organization of each center.
* First insertion for the treatment of a given event with an expected treatment duration of 28 days or less.
* Patients treated with a midline catheter at least 14 cm in length.

Exclusion Criteria:

* No coverage by the social security system
* Failure to insert the midline
* Patient under guardianship or conservatorship

Where this trial is running

Valenciennes

• Centre Hospitalier de Valenciennes — Valenciennes, France (RECRUITING)

Study contacts

• Study coordinator: Fanny DEFRANCQ, MD

Conditions: Veinous Access, Midline, Veinous Capital, midline, midline placement, midline indication, patient care