How nutritional measures relate to COVID-19 outcomes
Study on the Influence of Nutritional Indices on the Prognosis of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection
This will see if common nutrition measures (like prognostic nutritional index, geriatric nutritional risk index, BMI, and pectoralis muscle index) predict recovery or worsening in adults with COVID-19 treated at a hospital in Chongqing.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 800 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | The Second Affiliated Hospital of Chongqing Medical University Academic / other |
| Locations | 1 site (Chongqing, Chongqing Municipality) |
| Trial ID | NCT05835102 on ClinicalTrials.gov |
What this trial studies
This is a retrospective observational analysis of patients with confirmed SARS-CoV-2 infection treated at the Second Affiliated Hospital of Chongqing Medical University. Investigators collect demographics, clinical history, laboratory tests (including markers used to calculate PNI and GNRI), imaging (CT/MRI), and follow patients to discharge or death. They will use chi-square tests and logistic regression to link nutritional indices and muscle measurements to clinical outcomes while applying inclusion and exclusion criteria. The goal is to determine whether simple nutrition-related measures can help stratify prognosis and guide early nutritional interventions.
Who should consider this trial
Good fit: Adults with a positive SARS-CoV-2 nucleic acid or antigen test who received care at the Second Affiliated Hospital of Chongqing Medical University and meet the study's inclusion/exclusion rules are the intended candidates.
Not a fit: Patients with end-stage malignant tumors, those fully dependent on enteral or parenteral nutrition, people who are paralyzed, or intravenous drug users were excluded and are unlikely to benefit from these prognostic nutrition measures.
Why it matters
Potential benefit: If successful, clinicians could use straightforward nutrition measures to identify higher-risk COVID-19 patients earlier and target nutritional support to improve recovery.
How similar studies have performed: Previous research has linked malnutrition and indices such as PNI and GNRI to worse COVID-19 outcomes, so this approach has supporting evidence though predictive models vary by setting.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Patients with a positive SARS-CoV-2 nucleic acid test or a positive SARS-CoV-2 antigen test. Exclusion Criteria: 1. People with end-stage malignant tumors; 2. Nutritional intake disorders, mainly dependent on enteral and parenteral nutrition supporters; 3. paralyzed; 4. Intravenous drug addicts.
Where this trial is running
Chongqing, Chongqing Municipality
- The Second Affiliated Hospital of Chongqing Medical University — Chongqing, Chongqing Municipality, China (Recruiting)
Study contacts
- Study coordinator: Juan Kang, M.D.
- Email: 68368892@qq.com
- Phone: 8613996112052
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.