How much remifentanil is needed to prevent blood pressure and heart-rate spikes during intubation with etomidate plus lidocaine or sufentanil

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center randomized controlled trial uses a modified sequential method to find the effect-site target concentration of remifentanil (EC50 and EC90) that suppresses cardiovascular responses to tracheal intubation. ASA I–II adult patients undergoing elective general anesthesia with endotracheal intubation are randomized into three groups to receive saline, lidocaine, or sufentanil alongside etomidate for induction, followed by target-controlled infusion of remifentanil. The primary outcome is the median effective effect-site concentration (EC50) of remifentanil for blunting the intubation response, with secondary outcomes including EC90 and changes in mean arterial pressure, heart rate, and bispectral index around intubation. Each group plans to enroll about 33 patients for a total of 99 participants.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients scheduled for elective surgery under general anesthesia with endotracheal intubation;
* Classified as ASA physical status I-II.

Exclusion Criteria:

* Age \<18 years or \>65 years;
* Body mass index (BMI) \>30 kg/m² or \<18.5 kg/m²;
* Diagnosis of hypertension or severe cardiovascular diseases (including myocardial infarction, heart failure, atrial fibrillation, atrioventricular block, moderate-to-severe valvular diseases) or respiratory diseases (including acute exacerbation of chronic obstructive pulmonary disease, acute respiratory distress syndrome, acute asthma attack, moderate-to-severe pulmonary hypertension, severe pneumonia);
* Diagnosis of obstructive sleep apnea syndrome or history of difficult intubation or preoperatively anticipated difficult airway;
* Renal, hepatic or hematologic diseases;
* High risk of aspiration or reflux;
* Current use of analgesics for chronic pain or β-blockers for cardiovascular diseases;
* Current use of psychotropic medications;
* Contraindications to remifentanil or sufentanil, including: known hypersensitivity to any component of these drugs or other fentanyl analogues, current use of monoamine oxidase inhibitors, myasthenia gravis or conditions predisposing to respiratory depression, bronchial asthma or related disorders;
* Contraindications to lidocaine, including: known allergy to local anesthetics, concurrent Adams-Stokes syndrome, Wolff-Parkinson-White syndrome, or severe cardiac conduction block.

Where it's running

• Peking University Shenzhen Hospital
  Shenzhen, Guangdong, China Recruiting

Study contacts

• Principal investigator: Tao Luo — Peking University Shenzhen Hospitai
• Study coordinator: zhencong jiang
• Email: jzcmichael@163.com
• Phone: +8613148861770

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Heart rhythm and blood flow changes during pregnancy and after birth

  This project will test whether measuring heart rate variability and blood pressure can track heart and circulation changes in pregnant people from the third month through the postpartum period.

  Recruiting Fundacin Biomedica Galicia Sur · Vigo, Pontevedra · NCT07376616

• Virtual reality versus IV dexmedetomidine to reduce maternal anxiety during cesarean delivery

  This study will test whether virtual reality or an IV dexmedetomidine infusion better reduces anxiety, stabilizes blood pressure and heart rate, and improves newborn breathing and heart rate in women having elective cesarean delivery under neuraxial anesthesia.

  Recruiting Benha University · Banhā, Benha · NCT07343843

• Gradual versus intermittent tourniquet release during upper limb surgery in people with high blood pressure

  This trial will test whether gradual or intermittent tourniquet release better prevents sudden blood pressure and acid-base changes in people with high blood pressure having upper-limb orthopedic surgery under general anesthesia.

  Recruiting Kasr El Aini Hospital · Cairo · NCT07290504

• Timing nalbuphine for pain relief and blood pressure control during knee replacement in older adults

  We will test whether giving nalbuphine at different times during knee replacement helps control pain and stabilize blood pressure in people 65 and older.

  Recruiting Phase 4 Qianfoshan Hospital · Jinan, Shandong · NCT07271849

• Impact of Operating Room Noise on BIS and Hemodynamics During General Anesthesia

  This study tests whether higher operating room noise affects BIS readings and blood pressure and heart rate in adults having general anesthesia.

  Recruiting Başakşehir Çam & Sakura City Hospital · Başakşehir, Istanbul · NCT07194707

• Laparoscopic removal of splenic artery aneurysm with spleen preservation

  This study tries a minimally invasive laparoscopic operation that removes splenic artery aneurysms while saving the spleen in patients with aneurysms that are large, ruptured, or growing quickly, and checks immune function and nearby blood flow over a year.

  Recruiting Northern Jiangsu People's Hospital · Yangzhou, Jiangsu · NCT07053605

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.