How mechanical loading and bone loss change motor neuron reflexes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will record soleus muscle EMG, platform acceleration, and heel force while participants stand on a vibration platform to measure changes in the H-reflex under different mechanical loading conditions. A stimulating electrode will be placed over the tibial nerve to elicit the H-reflex while data are sampled at 2 kHz and analyzed using Spike2 software. The trial compares postmenopausal women with femoral osteoporosis to age-matched controls without osteopenia, excluding those with neurologic, muscular, significant lower-extremity pain, cardiac arrhythmias, or current osteoporosis treatment. Data will test whether load-sensitive bone signaling and muscle spindle reflex mechanisms correspond with suppressed or enhanced H-reflex responses during bone-loading activities.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Being in the postmenopausal period
* For the osteoporosis group: having femoral osteoporosis (femoral neck or total femur T-score ≤ -2.5)
* For the control group: having no osteoporosis or osteopenia (femoral neck and total femur T-scores \> -1, and L1-L4 and L2-L4 T-scores \> -1)
* Being a volunteer

Exclusion Criteria:

* Receiving osteoporosis treatment
* Having a peripheral or central nervous system disorder (e.g., stroke, polyneuropathy, radiculopathy, entrapment neuropathy, etc.)
* Having acquired or hereditary muscle diseases (myopathies)
* Having active painful lower extremity pathologies (e.g., osteoarthritis, inflammatory joint diseases, etc.)
* Having cardiac arrhythmias
* Having a history of other metabolic bone diseases
* Having skin lesions at the electrode placement sites on the lower extremities
* Being older than 65 years

Where it's running

• Istanbul Physical Medicine Rehabilitation Training & Research Hospital
  Bahçelievler, Istanbul, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Fuat Orhun Alayoğlu, Attending doctor
• Email: f.orhunalayoglu@gmail.com
• Phone: +905348431984

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.