How mannitol affects propofol levels during brain surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Forty adults (20 per group) undergoing supratentorial tumor or pituitary surgery at Çukurova University will be enrolled. All patients will receive target-controlled infusions set to propofol 4 µg/dl and remifentanil 2–4 µg/dl; the mannitol group will receive 2.5 ml/kg (0.5 g/kg) mannitol 20 minutes after induction over 10 minutes while the control group receives 2.5 ml/kg isotonic saline over 10 minutes. Blood and urine samples will be collected to measure propofol concentrations, and invasive hemodynamic monitoring plus bispectral index (BIS) will be recorded for all participants. Key exclusions include chronic kidney failure, sepsis, multiorgan failure, or ASA class III and above.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* American Society of Anesthesiologist (ASA) II participants
* supratentorial tumor surgery
* eligible for mannitol use
* eligible for Total intravenous anesthesia (TIVA)

Exclusion Criteria:

* American Society of Anesthesiologist (ASA) III and upper
* Chronic kidney failure
* sepsis
* multiorgan failure

Where it's running

• Çukurova University
  Çukurova, Adana, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Ebru Biricik
• Email: ebrubiricik01@gmail.com
• Phone: +905052420223

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.