How major respiratory viruses affect independence in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an international observational study enrolling people aged 60 and older who are hospitalized with PCR-confirmed influenza, SARS-CoV-2, respiratory syncytial virus, or human metapneumovirus. Participants' baseline function and clinical course during hospitalization will be recorded, and functional outcomes will be followed by phone at about 3 and 6 months after discharge. The study will compare loss of autonomy, changes in activities of daily living, and recovery trajectories across different viral causes and patient subgroups. Findings are meant to inform targeted prevention and vaccination strategies for older adults.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male or female subjects aged 60 years or older
* Hospitalized in a study center (emergency department, infectious disease, internal medicine or geriatric hospital wards…) for acute respiratory infection (refer to table 1 below for definition).
* Confirmed positive PCR test for influenza, SARS-CoV-2, RSV, or human metapneumovirus (hMPV). Participants with co-infections with other viral or bacterial agents can be included.

Exclusion Criteria:

* Participants with conditions significantly impacting short-term functional status, such as severe disability (ADL score ≤2 or Clinical Frailty Scale ≥7), terminal illness, palliative care needs, or inability to comprehend and complete study questionnaires due to severe stroke sequelae, complete sensory loss, advanced dementia, or similar impairments.
* Participants that refuse or are unable to answer the 3- and 6-months follow-up phone call assessments
* Positive laboratory test for single (mono-infection) virus other than influenza, SARS-CoV-2, RSV, or human metapneumovirus (HMPV)
* Participant in exclusion period for another study using an investigational / unapproved medicinal product.
* Participant referred to in articles L1121-5 to L1121-8 of the CSP (corresponding to all protected persons : pregnant woman, parturient, breastfeeding mother, person deprived of liberty by judicial or administrative decision, persons undergoing psychiatric care under articles L.3212-1 and L.3213-1 who do not fall under article L.1121-8, persons admitted to a healthcare or social institution for purposes other than research, minors, person under legal protection or unable to express consent).
* Individuals opposed to participating in the research
* Staff members with a hierarchical relationship to the principal investigator

Where it's running

• University of Rochester School of Medicine, Infectious Diseases Unit
  Rochester, New York, United States Recruiting
• Melun Hospital
  Melun, France Recruiting
• Hospital Clínic Barcelona Servicio de Geriatría
  Barcelona, Spain Recruiting
• University Hospital of Amiens
  Amiens, France Active not recruiting
• Villeneuve Saint Georges Hospital
  Paris, France Active not recruiting
• University Hospital of Poitiers
  Poitiers, France Active not recruiting

Study contacts

• Study coordinator: Gaetan GAVAZZI, MD,PhD
• Email: GGavazzi@chu-grenoble.fr
• Phone: 0033(0)476766760

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.