How lung surgery affects right ventricular function
Echocardiographic Assessment of Right Ventricular Function After Pulmonary Resection
This observational project will do heart ultrasounds before and after lung resection to see if right ventricular function and the PAP/TAPSE ratio change in adults having lung surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 25 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Gazi University Academic / other |
| Locations | 1 site (Ankara, yenimahalle) |
| Trial ID | NCT07042893 on ClinicalTrials.gov |
What this trial studies
This observational study enrolls adults 18–80 scheduled for elective lung resection and performs transthoracic echocardiography before and after surgery to measure right ventricular systolic function and pulmonary artery pressure, with emphasis on the PAP/TAPSE ratio. Key exclusions (arrhythmias, antiarrhythmic use, dialysis-dependent renal failure, prior lung surgery, significant valvular disease, recent MI/angina, or FEV1/FVC <60%) are used to reduce confounding. Serial echocardiographic measures will be compared perioperatively to quantify changes in right heart performance and their relationship to early postoperative outcomes. No therapeutic interventions are assigned; data are analyzed to describe patterns of right ventricular dysfunction following pulmonary resection.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18–80 with ASA I–III who are scheduled for elective lung resection and who do not have arrhythmia, recent myocardial infarction, significant valvular disease, prior lung surgery, dialysis-dependent renal failure, or severe airflow obstruction (FEV1/FVC <60%).
Not a fit: Patients with active arrhythmias, on antiarrhythmic drugs, dialysis-dependent renal failure, recent MI/angina, significant valvular disease, prior lung surgery, or very low lung function (FEV1/FVC <60%) are excluded and unlikely to benefit from the study findings.
Why it matters
Potential benefit: If perioperative changes in the PAP/TAPSE ratio identify patients at higher risk, clinicians could increase monitoring or adjust care to reduce cardiorespiratory complications after lung resection.
How similar studies have performed: Prior echocardiography studies have shown that TAPSE and pulmonary pressure measures relate to outcomes after thoracic and cardiac procedures, so focusing on the PAP/TAPSE ratio builds on existing observational evidence rather than testing a new therapy.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Adults aged 18 to 80 years ASA classification I-III Patients scheduled to undergo lung resection in thoracic surgery Exclusion Criteria: Patients with arrhythmia Patients using antiarrhythmic drugs Patients with renal failure requiring hemodialysis Patients with a history of previous lung surgery Patients with valvular heart disease Patients with a history of angina pectoris or myocardial infarction within the past month Patients with FEV1/FVC ratio below 60%
Where this trial is running
Ankara, yenimahalle
- Gazi University Faculty of Medicine, Ankara — Ankara, yenimahalle, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Çağrı Özdemir
- Email: cagriozdemir@gazi.edu.tr
- Phone: +905544239196
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.