How inflammation severity and miR-126 change after severe trauma
Official title: Correlation of Inflammation Severity With Pulmonary Gas Exchange and MiRNA 126 in Trauma Patients
Run by Akdeniz University · NCT07291908 · Data updated 2026-11-12
This study will test whether blood levels of miR-126 track inflammation and lung injury in adults treated for severe trauma in the ICU.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 130 (estimated) |
| Sponsor | Akdeniz University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Antalya, Ağrı) |
| Status | Recruiting |
| Started | June 17, 2025 |
| Main results expected | September 10, 2026 |
| Study ends | January 10, 2027 |
| Registry record updated | December 18, 2025 |
| Trial ID | NCT07291908 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 or older admitted to the anesthesia ICU within 24 hours of trauma who remain in the ICU at least 72 hours and do not have thoracic trauma, active pre‑trauma infection, immunodeficiency, ongoing shock, or prior steroid/chemotherapy/antibiotic therapy.
✕Probably not a fit
Patients with thoracic trauma, active infection before injury, immunodeficiency, children under 18, those in shock, or patients discharged from ICU within 72 hours are unlikely to benefit from this observational protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational study enrolling adult trauma patients admitted to the anesthesia intensive care unit to measure inflammatory markers and circulating miR-126 over the early post‑trauma period. Researchers will correlate miR-126 levels with clinical markers of endothelial injury, development of acute lung injury/ARDS, and organ dysfunction. Patients with thoracic trauma, preexisting infection, immunodeficiency, recent steroids/chemotherapy/antibiotics, or very short ICU stays are excluded to reduce confounding. The aim is to identify patterns linking microRNA signals to clinical outcomes rather than to test an intervention.
Why it matters
Potential benefit: If successful, this could help identify patients at higher risk for ARDS and organ dysfunction so clinicians can target monitoring or early interventions.
How similar studies have gone: Prior laboratory and observational work links miR-126 to endothelial function and inflammation, but using it as a clinical predictor after major trauma remains relatively novel and not yet validated.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Adults aged 18 years or older. Patients monitored and treated for trauma in the anesthesia intensive care units of Akdeniz University Faculty of Medicine. Exclusion Criteria: Patients younger than 18 years. Patients with concomitant thoracic trauma. Presence of active infection prior to trauma. Patients not admitted to the ICU within the first 24 hours after trauma. Patients who remain in the ICU for less than 72 hours following trauma. Current use of steroids, chemotherapy, or antibiotic therapy prior to ICU admission. Patients with immunodeficiency. Patients who are in shock prior to or during ICU admission.
Where it's running
-
Akdeniz University Hospital
Antalya, Ağrı, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: Canberk Kurban, Resident Physician — Department of Anesthesiology and Reanimation, Akdeniz University Hospital
- Study coordinator: Melike Cengiz, Prof Dr
- Email: melikecengiz@yahoo.com
- Phone: +905424317975
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.