How hormone and digestion functions and outcomes change after pancreas surgery

The Analysis of Endocrine-exocrine Functions and Prognosis After Pancreatectomy

This project will look back at medical records to see if different pancreatectomy methods, margin clearance, and how much pancreas is left affect hormone (endocrine) and digestion (exocrine) function and overall outcomes in adults who had pancreas surgery at our hospital.

Quick facts

• Study type: Observational
• Enrollment: 3500 (estimated)
• Ages: 20 Years to 75 Years
• Sex: All
• Sponsor: National Taiwan University Hospital (other)
• Locations: 1 site (Taipei, Taiwan)
• Trial ID: NCT07396662 on ClinicalTrials.gov

What this trial studies

This is a retrospective observational project using records from patients who underwent pancreatectomy at National Taiwan University Hospital. Investigators will collect baseline data, preoperative and postoperative blood tests (including blood counts, biochemistry, tumor markers, glucose- and lipid-related tests), and pre/postoperative imaging (CT, MRI, ultrasound, PET, endoscopy). They will compare surgical approach, margin clearance rates, and remnant pancreatic volume against changes in endocrine and exocrine function, quality of life, and disease prognosis. Analysis aims to identify surgery-related factors linked to functional outcomes and long-term prognosis.

Who should consider this trial

Good fit: Adults aged 20 to 75 who underwent pancreatectomy at National Taiwan University Hospital with available preoperative and postoperative clinical, laboratory, and imaging data are ideal candidates for inclusion.

Not a fit: Patients younger than 20, older than 75, pregnant individuals, or those without adequate pre/postoperative records are unlikely to be included or benefit from the study findings.

Why it matters

Potential benefit: If successful, the findings could help surgeons and clinicians choose approaches and follow-up care that better preserve pancreatic function and improve quality of life and prognosis after pancreatectomy.

How similar studies have performed: Prior research has shown that pancreatic resection commonly affects endocrine and exocrine function and that remnant pancreatic volume relates to diabetes risk, so this retrospective comparison builds on established findings rather than being entirely novel.

Eligibility criteria

Inclusion Criteria:

* All patients scheduled for pancreatectomy

Exclusion Criteria:

* Age under 20 years or older than 75 years; Pregnancy

Where this trial is running

Taipei, Taiwan

• National Taiwan University Hospital — Taipei, Taiwan, Taiwan (RECRUITING)

Study contacts

• Study coordinator: Yu Wen Tien, Ph.D.

Conditions: Pancreatic Neoplasm