How hippocampus and frontoparietal brain regions develop to support memory and reasoning

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This serial cohort study uses associative and probabilistic inference tasks performed during fMRI to examine how hippocampal, ventromedial prefrontal, and parietal cortical representations change with age. Adolescents (13–18 years) are scanned at three timepoints spaced 1.5 years apart, and adults (19–25 years) are scanned once to provide a reference. The study combines behavioral measures of associative and probabilistic inference with neuroimaging of retrieval and encoding processes to test whether memory representations become more integrated and hierarchically organized across development. Connectivity and representational analyses will probe shifts from simple episodic encoding to richer cross-episode linking supported by frontoparietal networks.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Right-handed
* Have normal or corrected to normal vision
* Have normal hearing
* Do not have contraindications for MRI
* Have no history of neurological or psychiatric disorders at initial intake
* Are of normal intelligence
* Native or fluent English speaker

Exclusion Criteria:

* A major medical illness or a neurological disorder, or neurological abnormality including significant head trauma (loss of consciousness \> 5 min).
* Meeting criteria for any psychiatric disorder or any prior psychiatric hospitalizations
* Intelligence scores more than 1 standard deviation below the mean on the WASI-II
* History of special education placement
* Non-native English speaker
* Prior use of psychotropic medication, except antidepressants, for longer than 1 month
* History of moderate to severe cannabis use disorder, via self-report
* MRI exclusions: Claustrophobia; tattoos above the shoulders; permanent eyeliner; permanent retainer or spacer; artificial eyebrows; cardiac pacemaker; metal fragments in eye, skin, or body, including shrapnel; heart valve replacement; brain clips; venous umbrella; being a sheet-metal worker or welder; lifetime history of aneurysm surgery; intracranial bypass, renal, or aortic clips; prosthetic devices such as middle ear, eye, joint, or penile implants; joint replacements; non-removable hearing aid, neurostimulator, or insulin pump; shunts/stents; metal mesh/coil implants; metal plate/pin/screws/wires; or any other metal implants; or suspected pregnancy.

Where it's running

• The University of Texas at Austin
  Austin, Texas, United States Recruiting

Study contacts

• Study coordinator: Alison R Preston, PhD
• Email: apreston@utexas.edu
• Phone: 512-475-7255

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.