How gut bacteria from women with eating disorders affect digestion and behavior

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will collect stool samples from women aged 18–50 who present with anorexia nervosa, bulimia nervosa, or binge-eating disorder at Rouen University Hospital, and from matched healthy female volunteers. Fecal microbiota from these donors will be transferred into mice to see whether recipient animals develop changes in intestinal physiology, digestion, or behaviors related to eating. Results from mice receiving microbiota from patients will be compared with those receiving microbiota from healthy donors to test for a causal role of dysbiosis. The work aims to clarify microbiota-driven mechanisms that could underlie or perpetuate eating disorder symptoms and related digestive problems.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Patients with ED

* Women.
* Aged 18 to 50.
* First consultation in the Nutrition Department of Rouen University Hospital for ED.
* Positive SCOFF with diagnosis of anorexia nervosa, bulimia nervosa, or binge eating disorder.
* Affiliation with a social security plan.
* Patient who has read and understood the information letter and does not object to participating in the study.

Healthy Volunteers

* Women.
* Aged 18 to 50.
* Body mass index between 18.5 and 24.9 kg/m².
* SCOFF test: no positive response.
* No history of ED or active ED (DSM V criteria negative).
* Affiliation with a social security plan.
* Individual who has read and understood the information letter and does not object to participating in the study.

Exclusion Criteria:

Patients with ED

* Men.
* Aged under 18 and over 50.
* Negative SCOFF.
* Patients who have received antibiotic treatment in the last 3 months.
* Patients with a history of IBD or surgical procedures on the digestive tract.
* Patient refuses to participate in the study.
* Persons deprived of liberty by judicial or administrative order.
* Pregnant or breastfeeding women.
* Protected persons (guardianship or curatorship).

Healthy volunteers

* Men.
* Aged under 18 and over 50.
* SCOFF test with at least one positive response.
* History or active ED (DSM V criteria).
* Persons who have received antibiotic treatment in the last 3 months.
* Person with a history of IBD or surgical procedures on the digestive tract.
* Body mass index less than 18.5 or greater than 24.9 kg/m2.
* Pregnant or breastfeeding women.
* Protected persons (guardianship or curatorship).

Where it's running

• University Rouen Hospital
  Rouen, France Recruiting

Study contacts

• Study coordinator: Pierre PD DECHELOTTE, Professor
• Email: Pierre.Dechelotte@chu-rouen.fr
• Phone: 02 32 88 64 65

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.