How giving fluids changes tiny blood flow in critically ill patients with venous congestion.
Evaluation of the Microcirculatory Response to Fluids in Critically Ill Patients With Venous Congestion: A Prospective Observational Study
This project will see if giving a fluid bolus makes tiny blood flow worse in ICU patients who have venous congestion compared with similar patients without congestion.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Università Politecnica delle Marche Academic / other |
| Locations | 1 site (Ancona, Italy) |
| Trial ID | NCT07499401 on ClinicalTrials.gov |
What this trial studies
This is a prospective observational study enrolling critically ill patients in the intensive care unit who have invasive or minimally invasive hemodynamic monitoring. Patients who receive a clinician-ordered fluid challenge will have microcirculatory measurements taken before and after the fluid is given. Investigators will compare microcirculatory changes between patients with clinical signs of venous congestion and those without. The aim is to determine whether fluid administration worsens microvascular perfusion in patients with venous congestion.
Who should consider this trial
Good fit: Critically ill ICU patients with invasive or minimally invasive hemodynamic monitoring who are undergoing a clinician-ordered fluid challenge are the intended participants.
Not a fit: Patients who are pregnant, those who cannot have oral-cavity or bedside microcirculatory measurements (for example due to facial trauma), or those without appropriate hemodynamic monitoring are unlikely to be eligible or benefit.
Why it matters
Potential benefit: If the study shows harm from fluids in congested patients, it could help clinicians avoid fluid strategies that worsen tissue perfusion.
How similar studies have performed: Previous work has looked at how fluids affect microcirculation in critically ill patients, but the specific effect in patients with venous congestion is less well characterized.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Critically ill patients admitted to the intensive care unit * Invasive or minimally invasive hemodynamic monitoring Exclusion Criteria: * Suspected or confirmed pregnancy * Inability to access the oral cavity (e.g., facial trauma, oral bleeding)
Where this trial is running
Ancona, Italy
- AOU delle Marche — Ancona, Italy, Italy (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.