How environmental pollutants relate to brain tumours, stroke, and Alzheimer's
Environmental Pollutants and Neurological Disorders: Clinical and Mechanistic Study
Beijing Tiantan Hospital · NCT07140601
This study will see if exposure to environmental pollutants is linked to brain tumours, cerebrovascular disease, and Alzheimer dementia in consenting adults, particularly those treated by neurosurgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Beijing Tiantan Hospital (other) |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Trial ID | NCT07140601 on ClinicalTrials.gov |
What this trial studies
This observational study will enroll adults with brain tumours, cerebrovascular disorders, or Alzheimer dementia at Beijing Tiantan Hospital to profile their environmental pollutant exposures and related molecular changes. Investigators will quantify traditional contaminants (lead, mercury, cadmium, arsenic) and emerging pollutants (micro- and nanoplastics, PFAS, antibiotics, endocrine disruptors) and collect biological samples to measure markers of oxidative stress, inflammation, epigenetic modifications, and metabolic reprogramming. The study will compare pollutant burdens and molecular signatures across diagnostic groups to identify associations with disease characteristics and possible pathogenic mechanisms. No investigational treatments are given; the focus is on exposure measurement and molecular correlation.
Who should consider this trial
Good fit: Adults aged 18 years or older with brain tumours, cerebrovascular disorders, or Alzheimer dementia who can give informed consent are the intended participants.
Not a fit: Pregnant or breastfeeding people and anyone who refuses or cannot provide informed consent are not eligible and would not benefit from participation.
Why it matters
Potential benefit: If successful, the work could identify pollutant exposures and molecular markers that help explain disease risk or progression and inform prevention or monitoring strategies.
How similar studies have performed: Prior studies have linked many pollutants to neurological harm, but comprehensive exposomics specifically in neurosurgical patient populations is relatively novel and not yet widely validated.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years of age or older; * Able to give informed consent to participate in the research. Exclusion Criteria: * Refusal to participate. * Pregnant or breastfeeding woman.
Where this trial is running
Beijing, Beijing Municipality
- Beijing Tiantan Hospital — Beijing, Beijing Municipality, China (RECRUITING)
Study contacts
- Study coordinator: Runting Li, MD
- Email: tt18080lrt@163.com
- Phone: +86 15753166690
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Cerebrovascular Disorders, Brain Tumours, Alzheimer Dementia, Environmental Pollutants, Exposomics, Pathogenic Mechanisms, Neurological Disorders, Neurosurgical Patients