How environmental pollutants relate to brain tumours, stroke, and Alzheimer's
Official title: Environmental Pollutants and Neurological Disorders: Clinical and Mechanistic Study
Run by Beijing Tiantan Hospital · NCT07140601 · Data updated 2026-11-12
This study will see if exposure to environmental pollutants is linked to brain tumours, cerebrovascular disease, and Alzheimer dementia in consenting adults, particularly those treated by neurosurgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Beijing Tiantan Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Status | Recruiting |
| Started | August 1, 2025 |
| Main results expected | December 31, 2025 |
| Study ends | August 1, 2027 |
| Registry record updated | August 24, 2025 |
| Trial ID | NCT07140601 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 years or older with brain tumours, cerebrovascular disorders, or Alzheimer dementia who can give informed consent are the intended participants.
✕Probably not a fit
Pregnant or breastfeeding people and anyone who refuses or cannot provide informed consent are not eligible and would not benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study will enroll adults with brain tumours, cerebrovascular disorders, or Alzheimer dementia at Beijing Tiantan Hospital to profile their environmental pollutant exposures and related molecular changes. Investigators will quantify traditional contaminants (lead, mercury, cadmium, arsenic) and emerging pollutants (micro- and nanoplastics, PFAS, antibiotics, endocrine disruptors) and collect biological samples to measure markers of oxidative stress, inflammation, epigenetic modifications, and metabolic reprogramming. The study will compare pollutant burdens and molecular signatures across diagnostic groups to identify associations with disease characteristics and possible pathogenic mechanisms. No investigational treatments are given; the focus is on exposure measurement and molecular correlation.
Why it matters
Potential benefit: If successful, the work could identify pollutant exposures and molecular markers that help explain disease risk or progression and inform prevention or monitoring strategies.
How similar studies have gone: Prior studies have linked many pollutants to neurological harm, but comprehensive exposomics specifically in neurosurgical patient populations is relatively novel and not yet widely validated.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years of age or older; * Able to give informed consent to participate in the research. Exclusion Criteria: * Refusal to participate. * Pregnant or breastfeeding woman.
Where it's running
-
Beijing Tiantan Hospital
Beijing, Beijing Municipality, China Recruiting
Study contacts
- Study coordinator: Runting Li, MD
- Email: tt18080lrt@163.com
- Phone: +86 15753166690
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.