How drinking enough water and choosing non-sugar sweetened drinks affects health
Official title: Adequate Hydration and Health Outcomes
Run by Arizona State University · NCT07179107 · Data updated 2026-11-12
We will test whether switching your usual drinks to plain water or to non-sugar sweetened beverages for three-week periods changes hydration, blood-sugar markers, and cardiovascular-related measures in adults 20–65 who are either normal weight or have obesity and have HbA1c ≤7%.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years to 65 Years |
| Sex | All |
| Enrollment | 144 (estimated) |
| Sponsor | Arizona State University Academic / other |
| Locations | 2 sites (Phoenix, Arizona and 1 other locations) |
| Status | Recruiting |
| Started | September 29, 2025 |
| Main results expected | July 2, 2028 |
| Study ends | December 31, 2028 |
| Registry record updated | January 27, 2026 |
| Trial ID | NCT07179107 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 20–65 with BMI 18.5–24.9 or 30.0–39.9 kg/m2, HbA1c ≤7%, and the ability to attend weekly in-person visits for eight consecutive weeks are ideal candidates.
✕Probably not a fit
People with diagnosed diabetes, HbA1c >7%, BMI 25–29.9 or ≥40 kg/m2, significant kidney, liver, or cardiac disease, or those on medications or with work/lifestyle factors that affect fluid balance are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Participants are screened with consent, medical history, body measurements, and a finger-stick HbA1c and then assigned by BMI category (normal weight or obesity) into an 8-week crossover protocol. After a baseline week of usual fluid intake, each participant completes two 3-week intervention periods in random order: one period consuming only plain water and one consuming only non-sugar sweetened beverages, separated by a washout week. Subjects attend weekly visits for measurements and monitoring, and those with HbA1c >7% are excluded and referred appropriately. The study compares short-term changes in hydration markers, metabolic measures, and cardiovascular-relevant signals between the beverage conditions.
Why it matters
Potential benefit: If successful, the findings could show that modest, low-cost changes in beverage choice improve hydration and lower markers linked to diabetes and cardiovascular risk.
How similar studies have gone: Observational studies have linked higher water intake and lower vasopressin activity to better metabolic and kidney outcomes, but randomized crossover trials directly comparing plain water to non-sugar sweetened beverages are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * BMI 18.5-24.9 or 30.0-39.9 kg/m2 * HbA1c ≤7% * Age 20-65 y * available for 8 consecutive weeks same day and time Exclusion Criteria: * Diabetes * HbA1c \>7% BMI ≤18.5, BMI of 25 to \<30, or ≥ 40 kg/m2 * night shifting work * losing or gaining weight during the last 2 months (\>5 lbs. fluctuation) * thyroid medication * bariatric surgery * Habitual strenuous exercise (\>120 min/week) Strenuous exercise is defined as activities that take hard physical effort and make you breathe much harder than normal. * Construction and other workers that spend signifant portion of their work day outdoors * Commuting by bicycle * Eating disorders * Use of aspirin during the duration of the study * Cancer * Renal disease (including kidney stones or recurrent urinary track infections * Hepatic disease * Cardiac conditions * Current infection requiring medication * Chronic, contagious, infectious diseases such as tuberculosis, Hepatitis A, B, C, or HIV * Medication that could affect appetite or body weight regulation * GLP1-RA medication * Anti-depressent SSRI medication * Testosterone replacement therapy * Participating in another study at the same time * Unable to abstain from alcohol during the study * Unable to limit caffeinated beverage intake to 1 cup per day * Donated blood during the past two months * Uneasibly acessable veins * Does not have smart phone
Where it's running
-
850 Pbc
Phoenix, Arizona, United States Recruiting -
850 Phoenix Bioscience Core
Phoenix, Arizona, United States Not yet recruiting
Study contacts
- Study coordinator: Holly Emmanuel
- Email: hydrate.study@gmail.com
- Phone: 602-935-7138
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.