How different heart-lung machine methods affect brain blood flow during CABG

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational study enrolling 70 adults (ASA II-III) undergoing elective CABG to compare cerebral perfusion when using MiECC versus conventional reservoir-based extracorporeal circulation. Researchers will non-invasively monitor intracranial pressure surrogate changes using optic nerve sheath diameter and track cerebral oxygenation with near-infrared spectroscopy during surgery. The study aims to clarify how different bypass techniques influence cerebral perfusion and associated postoperative neurological risk. Enrollment spans February 2026 to February 2027, with assignment based on the chosen extracorporeal circulation technique. The investigation addresses a gap in understanding the relationship between bypass methods, intracranial pressure markers, and cerebral oxygenation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* Scheduled for elective coronary artery bypass graft (CABG) surgery
* American Society of Anesthesiologists (ASA) physical status II-III
* Planned use of extracorporeal circulation during surgery
* Ability to provide written informed consent

Exclusion Criteria:

* Age \< 18 years
* ASA physical status other than II-III
* Emergency surgery
* Pregnancy
* History of neurological disease affecting consciousness or decision-making capacity
* History of psychiatric disease affecting decision-making capacity
* History of head trauma within the previous 24 hours
* Presence of carotid artery stenosis or significant carotid artery disease
* Coagulation disorders (INR \> 1.25, aPTT \> 35 s, or platelet count \< 100,000/μL)
* Reoperation (redo cardiac surgery)
* Congestive heart failure
* Chronic kidney failure
* Sepsis
* Hypoxia
* Ocular trauma
* Optic nerve pathology

Where it's running

• Kosuyolu High Specialization Training and Research Hospital
  Istanbul, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Mustafa Burgaç — mustafaburgac@outlook.com
• Study coordinator: Mustafa Burgaç, himself
• Email: mustafaburgac@gmail.com
• Phone: 0 538 984 8198

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Lower pressure during laparoscopic surgery to prevent delirium in older adults

  In adults aged 60 and up having laparoscopic pelvic surgery, the study tests whether using a lower-than-usual intraabdominal pressure during the operation reduces postoperative delirium.

  Recruiting Benha University · Banhā, Qalyubia Governorate · NCT07906444

• Optic nerve ultrasound to detect brain inflammation and raised intracranial pressure

  This project will test whether bedside optic nerve ultrasound can quickly detect brain inflammation and high intracranial pressure in adults with suspected meningitis, encephalitis, stroke, or brain tumors.

  Recruiting at 2 sites Spitalul Clinic de Boli Infecțioase și tropicale "Dr. Victor Babeș" · Bucharest, Bucharest and 1 other locations · NCT07332234

• Examining eye conditions in patients with craniosynostosis

  This study looks at the eye problems that can happen in people with craniosynostosis to better understand their eye health and improve their care.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT06928727

• Investigating fluids for treating septic shock and intracranial hypertension

  This study tests if two different fluids can help people with septic shock and high pressure in the brain feel better and improve their condition.

  Recruiting Phase 2 University Hospital Pilsen · Pilsen, Czech Republic · NCT06634069

• Using external lumbar drainage to lower brain pressure in severe traumatic brain injury

  This study is testing if using a special drainage method can safely lower brain pressure in people with severe traumatic brain injuries while they receive standard care.

  Recruiting at 6 sites Brain Trauma Foundation · Gainesville, Florida and 5 other locations · NCT05889650

• Comparing non-invasive and invasive methods for measuring intracranial pressure in children

  This study is testing if non-invasive ways to measure brain pressure in kids, like ultrasound techniques, can be as accurate as the traditional invasive methods that come with risks.

  Recruiting Azienda Ospedaliera di Padova · Bologna and 5 other locations · NCT05340062

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.