How dexamethasone dose affects recovery and quality of life after total hip replacement

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The HIPSTER trial compares a single intraoperative IV dose of dexamethasone 5 mg versus 25 mg in older adults undergoing elective total hip arthroplasty under spinal anaesthesia. Participants receive one of the two doses during surgery and are followed for health-related quality of life and persistent pain up to three months postoperatively. The study builds on ERAS practices that use corticosteroids to reduce acute postoperative pain, nausea and fatigue, while specifically measuring longer-term patient-reported outcomes. Enrollment and follow-up take place at Ziekenhuis Oost-Limburg with standard perioperative care otherwise unchanged.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* aged 60 years or older;
* scheduled for elective total hip arthroplasty;
* procedure under spinal anaesthesia.

Exclusion Criteria:

* hip revision surgery (reoperation);
* bilateral total hip arthroplasty during the same procedure;
* known hypersensitivity to dexamethasone or other corticosteroids;
* chronic systemic use of corticosteroids, defined as daily corticosteroid therapy for \> 4 weeks within the last 3 months, with anticipated need for a perioperative stress dose of corticosteroids;
* active gastric of intestinal ulcers;
* lack of informed consent or inability to give informed consent;
* urgent, non-elective surgery.

Where it's running

• Ziekenhuis Oost-Limburg
  Genk, Belgium Recruiting
• Ziekenhuis Oost-Limburg
  Genk, Limburg, Belgium Not yet recruiting

Study contacts

• Study coordinator: Steven Thiessen
• Email: steven.thiessen@zol.be
• Phone: 3289804646

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.