How complex thoraco‑abdominal aortic aneurysm repair affects blood clotting and platelets
Official title: Coagulation Factors Alterations in Patients Undergoing Complex Thoraco-abdominal Aortic Aneurysm Repair (CoFA-TAAA); a Prospective Observational Study
Run by University of Thessaly · NCT06432387 · Data updated 2026-11-12
This will see if complex thoraco‑abdominal aortic aneurysm repair causes changes in blood clotting and platelet activation in patients immediately after surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 58 (estimated) |
| Sponsor | University of Thessaly Academic / other |
| Locations | 2 sites (Larissa, Thessaly and 1 other locations) |
| Status | Recruiting |
| Started | December 31, 2024 |
| Main results expected | June 1, 2027 |
| Study ends | July 20, 2027 |
| Registry record updated | May 7, 2026 |
| Trial ID | NCT06432387 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults scheduled for complex thoraco‑abdominal aortic aneurysm repair at Larissa University Hospital who can give informed consent and do not have recent surgery, known thrombophilia, or functional platelet dysfunction are ideal candidates.
✕Probably not a fit
Patients with known thrombophilia or platelet dysfunction, those who had surgery within the prior three months, those with ASA physical status greater than 3, or patients treated outside the enrolling center are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Consecutive patients undergoing complex thoraco‑abdominal aortic aneurysm repair at Larissa University Hospital will be enrolled and provide informed consent. Blood samples will be taken before surgery and in the immediate postoperative period to measure coagulation factors and markers of platelet activation. This is an observational protocol without changes to clinical care, focused on biochemical and hemostatic measurements. The working hypothesis is that longer procedures and more complex implants produce greater platelet activation and coagulation alterations.
Why it matters
Potential benefit: If findings confirm perioperative coagulation changes, they could guide closer monitoring or tailored anticoagulation after complex repairs to reduce clotting complications.
How similar studies have gone: Prior research on endovascular abdominal aortic repair has shown inflammation and platelet activation affecting coagulation, but specific data on complex thoraco‑abdominal repairs are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Consecutive patients undergoing complex thoraco-abdominal aortic aneurysm repair in University Hospital of Larissa, after informed consent will be included. Exclusion Criteria: * Refuse to participate * Prior surgery within 3 months * ASA PS \> 3 * Known medical history of thrombophilia or functional platelet dysfunction
Where it's running
-
Larissa University Hospital
Larissa, Thessaly, Greece Recruiting -
University of Thessaly
Larissa, Greece Active not recruiting
Study contacts
- Study coordinator: Eleni Arnaoutoglou, Prof
- Email: earnaout@gmail.com
- Phone: 6974301352
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.