How complex thoraco‑abdominal aortic aneurysm repair affects blood clotting and platelets

Coagulation Factors Alterations in Patients Undergoing Complex Thoraco-abdominal Aortic Aneurysm Repair (CoFA-TAAA); a Prospective Observational Study

This will see if complex thoraco‑abdominal aortic aneurysm repair causes changes in blood clotting and platelet activation in patients immediately after surgery.

Quick facts

• Study type: Observational
• Enrollment: 58 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: University of Thessaly (other)
• Locations: 2 sites (Larissa, Thessaly and 1 other locations)
• Trial ID: NCT06432387 on ClinicalTrials.gov

What this trial studies

Consecutive patients undergoing complex thoraco‑abdominal aortic aneurysm repair at Larissa University Hospital will be enrolled and provide informed consent. Blood samples will be taken before surgery and in the immediate postoperative period to measure coagulation factors and markers of platelet activation. This is an observational protocol without changes to clinical care, focused on biochemical and hemostatic measurements. The working hypothesis is that longer procedures and more complex implants produce greater platelet activation and coagulation alterations.

Who should consider this trial

Good fit: Adults scheduled for complex thoraco‑abdominal aortic aneurysm repair at Larissa University Hospital who can give informed consent and do not have recent surgery, known thrombophilia, or functional platelet dysfunction are ideal candidates.

Not a fit: Patients with known thrombophilia or platelet dysfunction, those who had surgery within the prior three months, those with ASA physical status greater than 3, or patients treated outside the enrolling center are unlikely to benefit from participation.

Why it matters

Potential benefit: If findings confirm perioperative coagulation changes, they could guide closer monitoring or tailored anticoagulation after complex repairs to reduce clotting complications.

How similar studies have performed: Prior research on endovascular abdominal aortic repair has shown inflammation and platelet activation affecting coagulation, but specific data on complex thoraco‑abdominal repairs are limited.

Eligibility criteria

Inclusion Criteria:

* Consecutive patients undergoing complex thoraco-abdominal aortic aneurysm repair in University Hospital of Larissa, after informed consent will be included.

Exclusion Criteria:

* Refuse to participate
* Prior surgery within 3 months
* ASA PS \> 3
* Known medical history of thrombophilia or functional platelet dysfunction

Where this trial is running

Larissa, Thessaly and 1 other locations

• Larissa University Hospital — Larissa, Thessaly, Greece (RECRUITING)
• University of Thessaly — Larissa, Greece (ACTIVE_NOT_RECRUITING)

Study contacts

• Study coordinator: Eleni Arnaoutoglou, Prof

Conditions: Thoraco-abdominal Aortic Aneurysm Repair, Coagulation Factors Alterations, Platelet Activation