How breath effort relates to ARDS progression in kids
Official title: Role of Dyspnea in the Progression of Pediatric Acute Respiratory Distress Syndrome
Run by Universidad Nacional Andres Bello · NCT07750288 · Data updated 2026-11-12
This study tests whether measurements of breathing effort and related signs can predict worsening ARDS in children who have acute respiratory distress.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 1 Month to 18 Years |
| Sex | All |
| Enrollment | 68 (estimated) |
| Sponsor | Universidad Nacional Andres Bello Academic / other |
| Locations | 1 site (Santiago) |
| Status | Recruiting |
| Started | July 13, 2026 |
| Main results expected | March 31, 2030 |
| Study ends | March 31, 2030 |
| Registry record updated | September 1, 2026 |
| Trial ID | NCT07750288 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Children under 18 with PARDS (per PALICC2 criteria) and whose guardians consent to participate.
✕Probably not a fit
Children without PARDS progression or those unable to undergo required monitoring may not benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study in pediatric ARDS investigates how dyspnea components such as respiratory drive, effort, and work of breathing relate to disease progression. Researchers will monitor noninvasive respiratory support, transitions to assisted ventilation, and weaning, while collecting data on mechanical thresholds that may signal worsening ARDS. The goal is to identify objective thresholds that could help predict outcomes and guide timely interventions. The study uses tools like surface electromyography and esophageal manometry to measure respiratory effort and related parameters. Results may inform when to escalate or adjust respiratory support to improve outcomes for children with PARDS.
Why it matters
Potential benefit: If successful, the findings could help clinicians tailor respiratory support timing to prevent ARDS progression in children.
How similar studies have gone: Prior research in adults and animal models suggests that excessive respiratory effort can worsen lung injury, but this study addresses pediatric-specific patterns and thresholds.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Children younger than 18 years old. * Diagnosis of pediatric ARDS, as defined by the 2023 Pediatric Acute Lung Injury Consensus Conference (PALICC2). * Consent to participate given by legal guardians. Exclusion Criteria: * Tracheostomy. * Neuromuscular disease. * Uncorrected congenital heart disease. * Contraindication to esophageal catheter (choanal atresia, esophageal issues, recent esophageal surgery, etc.) or EIT (pacemakers, defibrillators, and unstable fractures). * Emergency intubation.
Where it's running
-
Hospital El Carmen Dr. Luis Valentin Ferrada
Santiago, Chile Recruiting
Study contacts
- Study coordinator: Pablo Cruces, Full Professor
- Email: pablo.cruces@unab.cl
- Phone: (56)990200810
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.