How blood vessel walls age
Aging of the Vascular Wall
Centre Hospitalier Universitaire de Saint Etienne · NCT07122427
This project will test how arteries and veins age by collecting graft tissue from adults having coronary artery bypass grafting (CABG).
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire de Saint Etienne (other) |
| Locations | 1 site (Saint-Etienne, France) |
| Trial ID | NCT07122427 on ClinicalTrials.gov |
What this trial studies
This observational study collects vascular grafts from patients undergoing CABG to compare cellular and structural signs of aging in arteries versus veins. Lab analyses will examine endothelial cells, vessel wall stiffness and thickness, and platelet-related markers of senescence. Patients with hypertension, diabetes, or systemic inflammatory disease are excluded to reduce confounding. The work is performed at CHU Saint-Étienne and aims to map differences in aging processes across vessel types.
Who should consider this trial
Good fit: Adults scheduled for coronary artery bypass grafting at CHU Saint-Étienne who do not have hypertension, diabetes, or systemic inflammatory disease are the intended participants.
Not a fit: People with hypertension, diabetes, systemic inflammatory disease, or those not undergoing CABG are unlikely to be eligible or to directly benefit from this protocol.
Why it matters
Potential benefit: If successful, this could clarify which vessel types age faster and why, helping guide future prevention or targeted therapies for age-related cardiovascular disease.
How similar studies have performed: Previous work has shown endothelial cell aging and platelet changes with age, but direct artery-versus-vein comparisons using patient grafts are limited, making this approach relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Major patients requiring coronary artery bypass grafting (CABG). Exclusion Criteria: * Hypertension, diabetes, systemic inflammatory disease.
Where this trial is running
Saint-Etienne, France
- CHU Saint-Etienne — Saint-Etienne, France, France (RECRUITING)
Study contacts
- Principal investigator: Salvatore CAMPISI, MD — Centre Hospitalier Universitaire de Saint Etienne
- Study coordinator: Anne-Claire DUCHEZ, PhD
- Email: anne-claire.duchez@efs.sante.fr
- Phone: (0)477421423
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Vascular Risk, Aging Disorder, Cardiovascular diseases, Aging, Eendothelial dysfunction