How blood vessel walls age
Official title: Aging of the Vascular Wall
Run by Centre Hospitalier Universitaire de Saint Etienne · NCT07122427 · Data updated 2026-11-12
This project will test how arteries and veins age by collecting graft tissue from adults having coronary artery bypass grafting (CABG).
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Saint Etienne Academic / other |
| Locations | 1 site (Saint-Etienne, France) |
| Status | Recruiting |
| Started | July 17, 2025 |
| Main results expected | December 2026 |
| Study ends | December 2026 |
| Registry record updated | August 20, 2025 |
| Trial ID | NCT07122427 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults scheduled for coronary artery bypass grafting at CHU Saint-Étienne who do not have hypertension, diabetes, or systemic inflammatory disease are the intended participants.
✕Probably not a fit
People with hypertension, diabetes, systemic inflammatory disease, or those not undergoing CABG are unlikely to be eligible or to directly benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study collects vascular grafts from patients undergoing CABG to compare cellular and structural signs of aging in arteries versus veins. Lab analyses will examine endothelial cells, vessel wall stiffness and thickness, and platelet-related markers of senescence. Patients with hypertension, diabetes, or systemic inflammatory disease are excluded to reduce confounding. The work is performed at CHU Saint-Étienne and aims to map differences in aging processes across vessel types.
Why it matters
Potential benefit: If successful, this could clarify which vessel types age faster and why, helping guide future prevention or targeted therapies for age-related cardiovascular disease.
How similar studies have gone: Previous work has shown endothelial cell aging and platelet changes with age, but direct artery-versus-vein comparisons using patient grafts are limited, making this approach relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Major patients requiring coronary artery bypass grafting (CABG). Exclusion Criteria: * Hypertension, diabetes, systemic inflammatory disease.
Where it's running
-
CHU Saint-Etienne
Saint-Etienne, France, France Recruiting
Study contacts
- Principal investigator: Salvatore CAMPISI, MD — Centre Hospitalier Universitaire de Saint Etienne
- Study coordinator: Anne-Claire DUCHEZ, PhD
- Email: anne-claire.duchez@efs.sante.fr
- Phone: (0)477421423
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.