How antibiotic-resistant bacteria move between people, pets, and the environment
Dynamics of AMR Spread, Persistence and Evolution Between Humans, Animals and Their Environment
Assistance Publique - Hôpitaux de Paris · NCT06262009
This project will test whether people who live with dogs pick up antibiotic-resistant bacteria from their pets.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 525 (estimated) |
| Sex | All |
| Sponsor | Assistance Publique - Hôpitaux de Paris (other) |
| Locations | 1 site (Maisons-Alfort) |
| Trial ID | NCT06262009 on ClinicalTrials.gov |
What this trial studies
DYASPEO is an observational project in France that follows households where a dog and its owners live together to track transmission of extended-spectrum cephalosporin- and carbapenem-resistant bacteria. The team will collect stool samples from humans and dogs and combine microbiology, whole-genome sequencing, microbiome analysis, epidemiology, modelling, and social science interviews to map transmission routes. Sampling and analysis focus on carriage and genetic relatedness of resistant Enterobacteriaceae over time. The goal is to clarify how often and by which pathways companion animals contribute to human antimicrobial resistance carriage.
Who should consider this trial
Good fit: Ideal participants are French-speaking adults or children who own a dog recorded for surgery at the National Veterinary School Alfort and plan to live with that dog in the same household for the next three months and can give informed consent.
Not a fit: People who do not live with a dog, cannot provide consent, are under legal guardianship or custody restrictions, lack social security affiliation, or do not speak French are unlikely to be eligible or to benefit from participation.
Why it matters
Potential benefit: If successful, the project could help prevent human acquisition of resistant bacteria from pets by identifying transmission pathways and informing practical hygiene and veterinary measures.
How similar studies have performed: Previous studies have found higher carriage of resistant Enterobacteriaceae in farmers exposed to food animals, but direct transmission between companion animals and their owners has been much less studied and remains uncertain.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult or child planning to live in the same household as his/her dog during the three months following inclusion. * Planning to live in the same habitat in the next three months following inclusion (except for holidays). * Written consent of all adults and of at least one of the two parents for minors under parental authority. A different information note will be elaborated for each age category (6-10 yr-old, 10-15 yr-old and 16-18 yr-old). * Owning a dog recorded for a surgery at the National Veterinary School Exclusion Criteria: * Lack of signed informed consent * Subject in alternating custody * Subject under legal protection (guardianship) * Subject deprived of liberty under judicial constraint * Subject undergoing psychiatric care * Lack of affiliation to a social security scheme * Volunteers who do not speak/write French
Where this trial is running
Maisons-Alfort
- the National Veterinary School Alfort — Maisons-Alfort, France (RECRUITING)
Study contacts
- Principal investigator: Jean-Yves Madec, PHD — ANSES
- Study coordinator: Jean-Yves Madec, PHD
- Email: Jean-Yves.MADEC@anses.fr
- Phone: 06 85 08 93 30
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Antibiotic Resistant Strain, Transmission, Close-Contact, antibiotic resistant transmission, transmission between dog and human