How a prior early abortion affects later pregnancy complications and outcomes
Official title: Effects of Prior Induced Termination of Pregnancy on Complications and Pregnancy Outcomes.
Run by National Research Institute for Family Planning, China · NCT04183829 · Data updated 2026-11-12
This project will try to see if having an early induced abortion (before 12 weeks) changes the risk of complications or outcomes in later pregnancies for women who can be followed over time.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 40 Years |
| Sex | Women only |
| Enrollment | 20000 (estimated) |
| Sponsor | National Research Institute for Family Planning, China Government |
| Locations | 12 sites (Zhongshan, Guangdong and 11 other locations) |
| Status | Recruiting |
| Started | June 1, 2019 |
| Main results expected | December 2027 |
| Study ends | June 2028 |
| Registry record updated | September 12, 2025 |
| Trial ID | NCT04183829 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women under 40 who had an induced abortion before 12 weeks, are permanent residents at a participating site, can communicate and consent, and are willing to complete follow-up are ideal candidates.
✕Probably not a fit
Women over 40, those with a history of adverse pregnancy or childbirth, or those who cannot complete follow-up are not eligible and would not benefit from participation or the study findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective multicenter cohort enrolling women who had an induced abortion in early pregnancy (<12 weeks) at three hospitals across China and following them forward to document subsequent pregnancy outcomes. Investigators will collect clinical information and record pregnancy complications through scheduled follow-ups and medical records. Eligible participants are permanent local residents under 40 without a prior history of adverse pregnancy or childbirth and who can provide informed consent and reliable contact information. The multicenter design is intended to capture regional variation in real-world outcomes rather than test a specific treatment intervention.
Why it matters
Potential benefit: If successful, the results could help clinicians and patients better understand and discuss risks after an early abortion and guide pregnancy care to reduce complications.
How similar studies have gone: Some retrospective studies have reported small associations between prior abortion and later outcomes, but prospective multicenter evidence is limited and results are mixed.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * women have induced abortion in early pregnancy (\<12 weeks of gestation). * permanent population and no tendency to move. * normal language expression and understanding ability, able to understand research content. * be able and willing to provide written informed consent and effective contact information, and be willing to cooperate with follow-up investigations. Exclusion Criteria: * above the age of 40 * with history of adverse pregnancy and childbirth
Where it's running
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Zhongshan Boai Hospital
Zhongshan, Guangdong, China Recruiting -
Zhangjiakou Maternal and Child Health Hospital
Zhangjiakou, Hebei, China Recruiting -
Daqing People's Hospital
Daqing, Heilongjiang, China Recruiting -
Changzhou Maternal and Child Health Hospital
Changzhou, Jiangsu, China Recruiting -
Yangzhou Maternal and Child Health Hospital
Yangzhou, Jiangsu, China Recruiting -
People's Hospital of Inner Mongolia Autonomous Region
Hohhot, Mongolia Autonomous, China Recruiting
Show 6 more locations
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Zaozhuang Maternal and Child Health Hospital
Zaozhuang, Shandong, China Recruiting -
Taiyuan Maternal and Child Health Hospital
Taiyuan, Shanxi, China Recruiting -
Chongqing Health Center for Women and Children
Chongqing, China Recruiting -
Shenzhen Luohu Maternity and Child Healthcare Hospital
Shenzhen, China Recruiting -
Qingdao Maternal and Child Health Hospital
Qingdao, Shandong, China Completed -
Tanggu Maternal and Child Health Hospital
Tanggu, Tianjin Municipality, China Completed
Study contacts
- Principal investigator: Pei Kaiyan — National Research Institute for Family Planning (NRIFP)
- Study coordinator: Jiang Xue, M.D.
- Email: jiangxue012800@163.com
- Phone: +86 18011490663
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.