How a mother's immune system accepts pregnancy in the first trimester

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational, longitudinal study of people undergoing IVF/ICSI that collects blood before embryo transfer, during the first trimester, and after any miscarriage. Samples will be analyzed for immune cell composition, activation states, and cytokine profiles using advanced immunological assays. The design tracks immune changes from pre-implantation through early gestation to identify cellular and molecular signatures linked to successful implantation and tolerance. Results aim to generate markers that could inform future predictive tests or targeted interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Blood from patients will be included before and during pregnancies (or failed implantation) conceived through IVF/ICSI (Intracytoplasmic Sperm Injection) treatment and in case of miscarriage.

1. where the patient (pregnant person) was ≥ 18 years of age.
2. where the patient (pregnant person) signed a written informed consent.

Exclusion Criteria:

1. Certain maternal infections (HIV, Hepatitis B, Hepatitis C, Syphilis)
2. Patients under immunosuppressive medications (at time of blood sample collection)

Where it's running

• University Hospital Basel
  Basel, Switzerland Recruiting

Study contacts

• Study coordinator: Ursula Gobrecht-Keller, MD
• Email: ursula.gobrecht@usb.ch
• Phone: +41 61 265 93 37

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.