Homocysteine levels and early heart relaxation changes in newly diagnosed high blood pressure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, single-center observational cohort enrolling at least 500 adults diagnosed with essential hypertension within the previous six months. Participants undergo clinical evaluation, ambulatory blood pressure monitoring, ECG, laboratory testing including pooled plasma homocysteine measurement, and comprehensive transthoracic echocardiography with diastolic function and strain analysis when image quality permits. Participants are categorized by a homocysteine threshold of 15 µmol/L and groups are compared for diastolic dysfunction and left ventricular and atrial global longitudinal strain parameters. Clinical, laboratory, and echocardiographic data will also be used to develop a machine-learning model to help predict H-type hypertension.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18 years or older
* Newly diagnosed essential hypertension within the previous 6 months
* Ability and willingness to provide informed consent
* Availability for clinical evaluation, laboratory testing, ambulatory blood pressure monitoring, electrocardiography, and transthoracic echocardiography

Exclusion Criteria:

* Resistant hypertension
* Secondary hypertension
* Acute coronary syndrome within the previous 6 months
* Major surgery within the previous 6 months
* Known heart failure
* Pulmonary hypertension
* Congenital heart disease
* Atrial fibrillation or atrial flutter
* Moderate or severe valvular heart disease
* Chronic kidney disease
* Anemia
* Current folate, vitamin B12, or vitamin B6 supplementation or treatment
* Inadequate echocardiographic image quality for strain analysis
* Known systemic conditions that may significantly affect plasma homocysteine levels

Where it's running

• Necmettin Erbakan University Meram Faculty of Medicine
  Konya, Meram, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: yunus emre yavuz, MD — Necmettin Erbakan University
• Study coordinator: yunus emre yavuz, MD
• Email: eyavuz@erbakan.edu.tr
• Phone: +90 5306069194

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.