HomeLink2: structured home care with optional nutrition to reduce deaths after hospital discharge

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, three-arm trial enrolls adults living with HIV who were admitted to the internal medicine ward at Tshepong Hospital and live in the Matlosana sub-district. Participants are randomly assigned to standard post-discharge care, home-based medical assessments with adherence support and psychosocial counseling, or the same home-based care plus food parcels to support nutrition. The primary outcome is death within six months of discharge, with secondary outcomes including medication adherence, retention in care, and longer-term health measures; the design is a type-1 hybrid implementation-effectiveness trial to collect both outcome and implementation data. Home visits and structured follow-up are used to deliver the interventions and gather outcome information.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Documented HIV infection (either diagnosed during or prior to hospital admission), consisting of any clinical documentation, including a chart note of HIV positivity, Ritonavir-boosted darunavir (RVD) positivity, or antiretroviral therapy (ART) regimen documentation/prescription
* ≥18 years old as per hospital file or government issued document
* Self-report that the participant resides within Matlosana sub-district
* Admitted to an adult internal medicine ward at Tshepong Hospital
* Have spent at least 2 nights in the hospital prior to recruitment to the trial.
* Agree to post-discharge follow-up, including home visits
* Are able to provide informed consent or if lacking capacity to provide consent at the time of recruitment, as determined by the study team, have a next of kin able to provide informed consent.

Exclusion Criteria:

* Admitted to a non-medical (i.e., surgical, psychiatric, etc.) ward, admitted for elective reasons, or admitted to facilitate onward transfer to another hospital
* Participant or next of kin unable to provide written informed consent in any of the languages of the informed consents or spoken by the study team

Where it's running

• Tshepong Hospital
  Klerksdorp, North West, South Africa Recruiting

Study contacts

• Principal investigator: Neil Martinson — Perinatal HIV Research Unit (PHRU)
• Study coordinator: Tumelo Moloantoa
• Email: moloantoat@phru.co.za
• Phone: +27 084-302-6059

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.