Home GRASP program to improve arm function and quality of life after stroke
Official title: Effectiveness of the Home-Based Graded Repetitive Arm Supplementary Program Combined With Occupational Therapy Versus Conventional Occupational Therapy Alone on Quality of Life and Upper Limb Function After Stroke: A Randomized Controlled Trial
Run by Universidad Miguel Hernandez de Elche · NCT07146789 · Data updated 2026-11-12
This trial will try adding a home-based GRASP exercise program to usual occupational therapy to see if people 3 to 12 months after a single stroke with hemiparesis regain more arm function and improve quality of life.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | Universidad Miguel Hernandez de Elche Academic / other |
| Locations | 1 site (Valencia) |
| Status | Recruiting |
| Started | April 1, 2025 |
| Main results expected | December 30, 2026 |
| Study ends | February 28, 2027 |
| Registry record updated | August 28, 2025 |
| Trial ID | NCT07146789 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 years or older, 3 to 12 months after a single stroke with hemiparesis who can perform minimal wrist/finger extension or have caregiver support and can attend visits in the Valencia area.
✕Probably not a fit
People with other neurological disorders, severe shoulder pain that prevents exercise, major visual-perceptual deficits, or who cannot perform the exercises even with help are unlikely to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The trial randomizes adults to usual occupational therapy versus usual therapy plus the Spanish HomeGRASP program, a graded, repetitive arm exercise regimen delivered at home with weekly occupational therapist supervision. The HomeGRASP intervention is designed to increase upper-limb rehabilitation time by up to seven additional hours per week through structured practice grounded in motor learning. Eligible participants are adults 3–12 months after a single stroke with some active wrist or finger extension and the ability to follow instructions or receive caregiver assistance. Main outcomes include measures of upper-limb function, autonomy in activities of daily living, and quality of life assessed after the intervention period.
Why it matters
Potential benefit: If successful, the program could help stroke survivors regain more arm function and greater independence by increasing accessible rehabilitation time at home.
How similar studies have gone: Prior studies of GRASP and similar graded home exercise programs have shown improved upper-limb outcomes, although the Spanish HomeGRASP implementation in this setting is less extensively studied.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Be of legal age. * Have suffered only one stroke and be clinically stable. * At least 3 months must have passed since the stroke and less than 12 months. * Signing of informed consent * Be able to communicate any adverse effects (e.g. shoulder pain) * Be able to follow instructions and perform the exercises independently for one hour. If they are not able to do so, have the help of a caregiver to ensure that the exercises are performed. * Perform at least 10º of active wrist or finger extension. * Ability to raise the scapula of the affected upper limb against gravity. Exclusion Criteria: * Having neurological conditions other than stroke. * Experiencing excessive pain in the affected upper limb that prevents the patient from correctly performing the exercises proposed in the programme. Visual Analogue Scale (VAS \> 7). * Having a visual perception deficit that prevents the patient from correctly performing the exercises proposed in the programme. * Excessive muscle tone (spasticity or hypertonia) that prevents the person from correctly performing the exercises proposed in the programme. Asworth \> 2. * A Folstein Mini-Mental State Examination (MMSE) score of ≥22 is required.
Where it's running
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Fundación Hopitalarias, Centro sociosanitario Nuestra señora del Carmen
Valencia, Spain Recruiting
Study contacts
- Principal investigator: Eva María Navarrete Muñoz, Phd — Universidad Miguel Hernández de Elche.
- Study coordinator: Eva María Navarrete Muñoz, Phd
- Email: enavarrete@umh.es
- Phone: +34686587209
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.