Home-based rehabilitation for upper limb recovery after stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on improving upper limb function in patients who have experienced a chronic stroke through a home-based rehabilitation program. Participants will be randomly assigned to either an experimental group, which uses a specialized orthosis with dynamic resistance, or a control group that uses the orthosis without resistance. The program consists of two daily sessions over ten days, with remote supervision to ensure adherence and safety. The study aims to assess the effectiveness of dynamic perturbation training in enhancing motor recovery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Males and females aged 18 years or older;
* Diagnosis of first cerebral stroke (ischaemic or haemorrhagic) in the chronic phase (i.e. at least 6 months after the onset of the acute event) verified by brain imaging (brain computed tomography and/or magnetic resonance imaging);
* Motor deficit in the upper limb - and in particular in the hand - caused by stroke, not attributable to other conditions or diseases and not such as to preclude the ability to perform movements with the fingers and to perform movements to grasp objects;
* Ability to express informed consent correctly.
* Availability of a webcam and Internet connection at home for remote supervision of activities by the staff involved in the study.

Exclusion Criteria:

* Medical conditions that may interfere with the ability to safely complete the study protocol;
* Cognitive dysfunction that precludes informed consent;
* Severe neuropsychological disorders;
* Severe visual problems;
* Upper limb pain assessed with Visual Analogue Scale (VAS) \> 7;
* Severe internal diseases (e.g. cardiopulmonary, renal, hepatic);
* Diseases with inflammatory skin lesions, wounds, sensory and circulatory disorders below the elbow and on the hand in the area of application;
* Contraindications to transcranial magnetic stimulation (TMS) procedures, assessed as indicated by international reference, such as: presence of intracranial metal implants, positive history of epilepsy, frequent migraines, implantable devices (ventricular-peritoneal shunts, pacemakers, intrathecal pumps, intracranial metal implants). It should be noted that the presence of this type of exclusion criterion will preclude the performance of TMS assessments, but not the remaining procedures of the study;
* Pregnancy.

Where it's running

• Ferrara University Hospital
  Ferrara, Emilia-Romagna, Italy Recruiting

Study contacts

• Study coordinator: Sofia Straudi, MD PhD
• Email: strsfo@unife.it
• Phone: + 39 0532238830

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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  This project will test whether a detailed health and sample-collection approach (deep phenotyping) is practical and acceptable for people aged 18–55 who have had a stroke.

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• Stem cell therapy for chronic stroke recovery

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  Recruiting Phase 2 Hokkaido University Hospital · Sapporo, Hokkaido · NCT06752720

• AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals

  This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.

  Recruiting at 2 sites Hospital Universitari Vall d'Hebron Research Institute · Leuven and 6 other locations · NCT07924371

• Web-based therapy using action observation and mirror therapy for arm weakness after stroke

  This trial tests whether a mobile telerehabilitation app delivering action observation therapy (AOT) alone or combined AOT with mirror therapy (AOT-MT) can improve upper limb function in people with subacute stroke.

  Recruiting Chang Gung Memorial Hospital · Taoyuan · NCT07921108

• Remote Ischaemic Conditioning for Fatigue After Stroke 2

  Aat least 12 weeks after stroke, adults with post-stroke fatigue will try a simple hand-arm cuff treatment at home to see if it helps reduce fatigue.

  Recruiting Phase 2 Sheffield Teaching Hospitals NHS Foundation Trust · Sheffield, South Yorkshire · NCT07914647

• Dual-task balance training plus computer-based cognitive training after stroke

  In adults who recently had a stroke, the study tests whether adding computerized cognitive exercises to balance training improves balance and other recovery outcomes.

  Recruiting Matia Foundation · San Sebastián, GUIPUZCOA · NCT07913620

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.