Home-based intervention for infants with behavior problems

The PANTHERS (Parents and iNfants Together in Home-based Early Remote Services) Project

Not applicable Interventional Florida International University · NCT04594902

This study is testing a remote program to see if it can help reduce behavior problems in infants from high-risk families.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment288 (estimated)
Ages12 Months to 18 Months
SexAll
SponsorFlorida International University Academic / other
Locations2 sites (Miami, Florida and 1 other locations)
Trial IDNCT04594902 on ClinicalTrials.gov

What this trial studies

The PANTHERS Project evaluates the effectiveness of a remote home-based intervention called the Infant Behavior Program (IBP) aimed at reducing behavior problems in infants from high-risk families. Families will participate in five remote evaluations and receive six remote treatment sessions of either the IBP or an enhanced pediatric primary care (EPPC) program. The study employs a randomized controlled trial design, with assessments conducted before and after the intervention, as well as at multiple follow-up points over the course of a year.

Who should consider this trial

Good fit: Ideal candidates include infants aged 12 to 18 months with elevated behavior problem scores and their primary caregivers, who must be English or Spanish speakers.

Not a fit: Patients with major sensory impairments, significant cognitive delays in caregivers, or those involved with child protection services may not benefit from this study.

Why it matters

Potential benefit: If successful, this intervention could provide families with effective strategies to manage and reduce behavior problems in their infants.

How similar studies have performed: Other studies have shown success with similar remote intervention approaches, indicating potential for positive outcomes in this area.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Infants ages 12 to 18 months and at least one primary caretaker, who is at least 18-years-old and in most cases will be the mother
* Elevated score (\> 75th percentile) on the problem scale of the Brief Infant-Toddler Social and Emotional Assessment (BITSEA; Briggs-Gowan et al., 2004)
* An English-speaking or Spanish-speaking primary caregiver.

Exclusion Criteria:

* Infants with major sensory impairment (e.g., deafness blindness) or several problems that impair mobility (e.g., cerebral palsy)
* Significant cognitive delay in the primary caregiver (i.e., estimated IQ score \< 70 on the vocabulary subtest of the Wechsler Abbreviated Scale of Intelligence - Second Edition (WASI-II) for those speaking English or an average standard score \< 4 on the vocabulary subtest of the Escala de Inteligencia Wechsler Para Adultos - Third Edition (EIWA-III) for those speaking Spanish)
* Families involved with child protection services, which is expected to be low based on our pilot trials

Where this trial is running

Miami, Florida and 1 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Early Childhood DevelopmentBehavior Problems
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.