Home-based cognitive-motor training for multiple sclerosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project aims to evaluate the effectiveness of a home-based cognitive-motor training program for individuals with multiple sclerosis (MS). It will compare the combined cognitive-motor rehabilitation approach to traditional single cognitive and motor rehabilitation methods. The study will utilize a randomized controlled design across two centers, incorporating telemedicine to enhance accessibility. Participants will undergo assessments using MRI and EEG to identify changes in brain function and structure, as well as predictors of treatment response.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Clinically definite multiple sclerosis (revised McDonald criteria 2017)
* Expanded Disability Status Scale (EDSS) below 6.0
* Digit span backwards z-score between \[-3 and -0.5\] standard deviations below the median of the normative values
* Age between 18 and 65
* Able to safely perform motor rehabilitation in the home situation (assessed by rehabilitation physician and/or occupational or physiotherapist)

Exclusion Criteria:

* Cognitive rehabilitation within six months before inclusion
* Inpatient multidisciplinary rehabilitation program within three months before inclusion or planned inpatient program during trial
* Start of or switch in immunomodulator treatment within three months before inclusion
* Less than one month post-exacerbation
* Major psychiatric or medical disorder that could influence cognitive functions
* Combined vision with optimal correction below 0.6 on Snellen Visual Acuity Test
* Unable or unwilling to undergo EEG or MRI
* Refusing informed consent

Where it's running

• Universitair Ziekenhuis Brussel
  Brussels, Belgium Recruiting
• National MS Center Melsbroek
  Melsbroek, Belgium Recruiting

Study contacts

• Principal investigator: Guy Nagels — Vrije Universiteit Brussel, Universitair Ziekenhuis Brussel
• Study coordinator: Delphine Van Laethem
• Email: Delphine.Van.Laethem@vub.be
• Phone: +32 2 629 10 45

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.