Home air surveillance for respiratory infections (ORCHARDS-AIR)
ORegon CHild Absenteeism Due to Respiratory Disease Study - Air Surveillance
This project will test whether placing air-sampling devices in the homes of Oregon School District students and their household members can pick up viruses like influenza and SARS-CoV-2 and match what we find on their nasal swabs.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 422 (estimated) |
| Ages | 4 Years and up |
| Sex | All |
| Sponsor | University of Wisconsin, Madison Academic / other |
| Locations | 1 site (Madison, Wisconsin) |
| Trial ID | NCT07298967 on ClinicalTrials.gov |
What this trial studies
ORCHARDS-AIR places an indoor air sampling device in participants' homes and collects nasal swabs from symptomatic students and consenting household members. Researchers compare the viruses detected in the air with those found in individual nasal specimens to measure how often they match. They also examine whether higher rates of air detection are linked to greater household transmission and to student absenteeism. Participants are primarily students with recent acute respiratory symptoms who attend the Oregon School District and their household contacts in the Madison, Wisconsin area.
Who should consider this trial
Good fit: Ideal candidates are Oregon School District students with recent acute respiratory symptoms (at least two ILI/ARI symptoms) and their household members willing to provide nasal swabs and host an air monitor.
Not a fit: People without recent symptoms, those living outside the Oregon School District area, or anyone unwilling to allow an in-home device or provide nasal samples are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, home air monitoring could offer an easy way to spot household respiratory outbreaks earlier and guide steps to reduce spread.
How similar studies have performed: Previous research has detected respiratory viruses in air samples in clinical and community settings, but using routine home air monitors to predict household transmission remains relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria - Students: * Student attends, or is eligible to attend, a school within the Oregon School District (OSD) * Study has an illness characterized by at least 2 of 6 acute respiratory infection (ARI)/ILI symptoms (nasal discharge, nasal congestion, sneezing, sore throat, cough, fever) and student scores at least 2 points on the Jackson scale Exclusion Criteria - Students: * Household member listed on Wisconsin Department of Corrections Sex Offender Registry * Illness onset more than 7 days before anticipated time of specimen collection * Anatomical defect for which nasal specimen collection is contraindicated * Student participated too recently (\<7 days from day 14 during peak influenza / COVID-19 period and \<30 days during other times, as determined by a medically-attended surveillance program) Inclusion Criteria - Household member: * Live in the same household as eligible student participant * Any age and gender * Fluent in English * Able to provide appropriate consent or assent
Where this trial is running
Madison, Wisconsin
- University of Wisconsin-Madison — Madison, Wisconsin, United States (Recruiting)
Study contacts
- Principal investigator: Jonathan Temte, MD, PhD — University of Wisconsin, Madison
- Study coordinator: Shari Barlow
- Email: shari.barlow@fammed.wisc.edu
- Phone: 608-265-4348
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.