High-resolution retinal imaging for patients with inherited retinal degenerations
High Resolution Retinal Imaging in Patients With Inherited Retinal Degenerations
This study is testing advanced imaging techniques to see how inherited retinal diseases affect vision and to better understand the changes happening in the retina for people with conditions like retinitis pigmentosa and cone-rod dystrophy.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 400 (estimated) |
| Ages | 13 Years and up |
| Sex | All |
| Sponsor | University of California, San Francisco Academic / other |
| Locations | 1 site (San Francisco, California) |
| Trial ID | NCT00254605 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the structure and function of the retina in patients with inherited retinal degenerations using advanced imaging techniques such as the Adaptive Optics Scanning Laser Ophthalmoscope (AOSLO) and Optical Coherence Tomography (OCT). By correlating high-resolution images with standard vision measures, the study seeks to enhance understanding of vision loss mechanisms in conditions like retinitis pigmentosa and cone-rod dystrophy. The research will also explore the functionality of individual photoreceptors through a novel technique called microperimetry. Ultimately, the findings could provide valuable insights into the progression of retinal diseases and potential future therapeutic approaches.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with inherited retinal degenerations, such as retinitis pigmentosa, who can travel to the study location.
Not a fit: Patients with cataracts or irregular corneal astigmatism, as well as those who have undergone prior refractive surgery, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding of retinal degenerations, potentially guiding future treatments and interventions.
How similar studies have performed: Other studies utilizing advanced imaging techniques in retinal research have shown promise, suggesting that this approach may yield valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Subjects must speak and understand English * Subjects must have pupils that dilate to at least 6 millimeters diameter. * Subjects must be willing to travel to University of California (UC) Berkeley. * Subjects are financially responsible for their travel to the San Francisco area if they are not San Francisco residents. Exclusion Criteria: * Cataract * Irregular corneal astigmatism (keratoconus) * Prior refractive surgery
Where this trial is running
San Francisco, California
- Department of Ophthalmology Retinal Degenerations Clinic, UCSF — San Francisco, California, United States (Recruiting)
Study contacts
- Principal investigator: Jacque L. Duncan, M.D. — University of California, San Francisco
- Study coordinator: Jacque L. Duncan, M.D.
- Email: jacque.duncan@ucsf.edu
- Phone: 415-514-4241
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.