High-protein, high-fiber pre-fast meal effects on fullness and blood sugar during fasting
Effect of a High-Protein, High-Fiber Pre-Fast Meal on Satiety and Glycemic Profiles During Fasting: A Randomized Crossover Study
This test sees if eating a high-protein, high-fiber meal before a fasting period helps healthy adults feel fuller and keep blood sugar steadier than a low-protein, low-fiber meal.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 38 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | King Faisal University Academic / other |
| Locations | 1 site (Al-Ahsa, Eastern Province) |
| Trial ID | NCT07447505 on ClinicalTrials.gov |
What this trial studies
In a randomized crossover design, healthy adults will complete two pre-fast meal conditions in random order: a standardized high-protein, high-fiber meal (oats, Greek yogurt, peanut butter, dried cranberries, almonds) and a low-protein, low-fiber meal guided by written instructions. Each condition is followed for two consecutive days with a three-day washout between conditions to limit carryover effects. Subjective appetite sensations will be recorded at preset times during the fasting day using visual analogue-type scales, while continuous glucose monitoring (CGM) will capture glycemic profiles throughout each condition. Exploratory analyses will examine temporal associations between CGM-derived glucose dynamics and reported appetite sensations.
Who should consider this trial
Good fit: Healthy adults aged 18 and older who can fast, wear a continuous glucose monitor, and are not pregnant, lactating, diabetic, or allergic to the meal components are ideal candidates.
Not a fit: People with diagnosed diabetes or other metabolic diseases, those taking medications that affect glucose or appetite, pregnant or breastfeeding individuals, or anyone allergic to oats, dairy, peanuts, or nuts are unlikely to benefit and are excluded.
Why it matters
Potential benefit: If successful, this could provide a simple mealtime strategy to increase satiety and reduce blood sugar swings during fasting, making fasting periods more comfortable and metabolically stable for healthy adults.
How similar studies have performed: Previous short-term studies of higher-protein and higher-fiber meals have tended to reduce postprandial glucose spikes and increase feelings of fullness, so this study applies those concepts specifically to the pre-fast context.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 18 years and older * Willingness to comply with study procedures, including fasting and continuous glucose monitoring * Ability to provide informed consent Exclusion Criteria: * Diagnosed diabetes mellitus or known metabolic disease * History of cardiovascular, gastrointestinal, or endocrine disorders that may affect study outcomes * Use of medications known to affect glucose metabolism or appetite * Pregnancy or lactation * Known allergy or intolerance to any study meal components (oats, dairy, peanuts, nuts, cranberries)
Where this trial is running
Al-Ahsa, Eastern Province
- King Faisal University — Al-Ahsa, Eastern Province, Saudi Arabia (Recruiting)
Study contacts
- Study coordinator: Wafa Alotaibi
- Email: Walotaibi@kfu.edu.sa
- Phone: +966500358622
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.